Projects
Targeting MUC13 to sensitise colorectal cancer cells to cell death
About me
I have twenty years’ experience in molecular biology and cellular immunology with responsibility for managing a wide range of research projects. This has involved designing, scheduling and planning experiments, including setting up different assays and techniques, analysing results, documenting data and writing scientific papers.
I am currently a Senior Research Officer at the Mater Medical Research Institute, and my research focuses on identification and characterizing the role of cell surface mucins in infection, inflammation and cancer development. I have published 18 papers in high-ranking international journals, of which 10 have been first author.
Publications
- Das I, Png CW, Oancea I, Hasnain SZ, Lourie R, Proctor M, Eri RD, Sheng Y, Crane DI, Florin TH, McGuckin MA. 2013. Glucocorticoids alleviate intestinal ER stress by enhancing protein folding and degradation of misfolded proteins. J Exp Med. 210(6):1201-16. doi: 10.1084/jem.20121268
- Sheng YH, Triyana S, Wang R, Das I, Gerloff K, Florin TH, Sutton P, McGuckin MA. 2013. MUC1 and MUC13 differentially regulate epithelial inflammation in response to inflammatory and infectious stimuli. Mucosal Immunol. 6(3):557-68. doi: 10.1038/mi.2012.98.
- Sheng, YH, Hasnain, S.Z., Florin, T.H. & McGuckin, M.A. 2012. Mucins in IBD and Colorectal Cancer. J Gastroenterol Hepatol 27(1):28-38
- Sheng, YH, Hasnain, Png CW, McGuckin, M.A. & Lindén SK. 2012. Techniques for assessment of interactions of mucins with microbes and parasites in vitro and in vivo. Meth Mol Biol 842:297
- Sheng, YH, Lourie R, Lindén SK, Jeffery PL, Roche D, Tran TV, Png CW, Waterhouse N, Sutton P, Florin TH, McGuckin M.A. 2011. The MUC13 cell-surface mucin protects against intestinal inflammation by inhibiting epithelial cell apoptosis. Gut 60(12):1661.
- Lindén SK, Sheng YH, Every AL, Miles KM, Skoog EC, Florin TH, Sutton P, McGuckin MA. 2009. MUC1 limits Helicobacter pylori infection both by steric hindrance and by acting as a releasable decoy. PLoS Pathog. 5(10):e1000617
- Wilson J, Cullup H, Lourie R, Sheng Y, Palkova1 A, Radford K, Dickinson AM, Rice1 A, Hart D, Munster D. 2008. Antibody to the dendritic cell surface activation antigen CD83 prevents acute graft-versus-host disease. J Exp Med. 206(2):16
Research fields
The Role of MUC1 and MUC13 Cell Surface Mucins in cancer
