Projects
About me
Dr Tony Parker is the program leader of the Tissue Repair and Regeneration Program (TRR) at the Institute of Health and Biomedical Innovation (IHBI) at the Queensland University of Technology. He is also a Senior Lecturer within the School of Biomedical Sciences at QUT. Dr Parker’s PhD examined the role of extracellular matrix / growth factor complexes and their role in bone cell function. Since then his research has focussed on musculoskeletal and skin tissue injury and recovery. Much of his research activities are undertaken within the TRR’s Systems Biology Group, which conducts proteomics, metabolomics and cellular research into the mechanisms and biochemical implications of tissue injury and recovery processes and of health promoting physical activity. In particular, Dr Parker and his students and colleagues have developed the workflows required for the proteomic and metabolomic investigation of wound and tissue fluids at IHBI, QUT. In addition, he helped to establish the proteomics and metabolomics capability at QUTs Central Analytical Research Facility (CARF) at QUT's Gardens Point campus.
Publications
Sampson, D.L., Broadbent, J.A., Parker, A.W., Upton, Z., and Parker, T.J. (2014) Urinary biomarkers of physical activity: candidates and clinical utility. Expert Reviews in Proteomics, 11 (1): 91-106. (Invited Review). This was an invited review which is the first to discuss the utility of urinary proteins and metabolites as indicators of the perturbations which occur to human biochemistry across the physical activity spectrum (from too little to too much exercise).
Yan L, Nie W, Parker T, Upton Z, Haitao Lu. (2013) MS-based metabolomics facilitates the discovery of in vivo functional small molecules with a diversity of biological contexts. Future Medicinal Chemistry, 5 (16):1953-65.
Sampson, D.L., Chng, Y.L., Upton, Z., Hurst, C.P., Parker, A.W. and Parker, T.J. (2013) The Highly abundant urinary metabolite, urobilin, interferes with the bicinchoninic acid assay. Analytical Biochemistry, 422: 110-117.
Parker, T.J., Broadbent, J.A., McGovern, J.A., Broszczak, D.A., Parker, C.N. and Upton, Z. (2013) Provisional matrix deposition in haemostasis and venous insufficiency: Tissue pre-conditioning for non-healing venous ulcers. (Invited review), Accepted 05/7/2013: Published ahead of Print in Advances in Wound Care). This invited review is the first to consolidate several hypotheses about the cause and maintenance of chronic venous leg ulcers into the context of a failure to stop vascular leakage into the interstitial space and highlights the potential physiological and biochemical reasons why best practice compression therapy is still the most successful treatment and preventative measure for venous leg ulcers.
McGovern, J.A., Heinemann, J.R., Burke, L.J., Dawson, R., Parker, T.J., Upton, Z., Hooper J.D. and Manton K.J. (2013) Stratum basale keratinocyte expression of the cell surface glycoprotein CDCP1 during epidermogenesis and its role in keratinocyte migration. British Journal of Dermatology, 168: 496-503.
Broszczak, D., Stupar, D., Compay, A.L.L., Sharma, M.V.S., Parker, T.J., Shooter, G.K., Upton, Z. and Fernandez, M.L. (2012) Biochemical profiling of proteins and metabolites in wound exudates from chronic wound environments. Wound Practice & Research, 20 (2): 62-72. Here we describe the optimisation of sample collection and preparation of chronic wound fluid for proteomic and metabolomic analysis. This paper was awarded the Comfeel Literary Award for Best Original Research Article of 2012 in Wound Practice and Research.
Parker, T.J., Sampson, D. L., Broszczak, D., Chng, Y.L., Carter, S.L., Leavesley, D.I., Parker, A.W. and Upton Z. (2012) A fragment of the LG3 peptide of endorepellin is present in the urine of physically active mining workers: A potential marker of physical activity. PLoS ONE. 7 (3): e33714. This is the first study to associate variation in the levels of urinary LG3 peptide with having been physically active. Since LG3 is a bioactive peptide this has implications for links between its biological role in vivo (angioregulation) and physical activity / exercise.
Sampson, D.L., Parker, T.J., Upton, Z., Hurst, C.P. (2011) A comparison of methods for classifying clinical samples based on proteomics data: A case study for statistical and machine learning approaches. PLoS ONE. 6 (9): e24973. This paper compared various statistical and machine learning techniques for analysing clinical proteomic data sets. We demonstrated that Support Vector Machines and in particular PLS approaches offer the best potential for the analysis of highly dimensional proteomic data.
Doran, M.R., Mills, R.J., Parker, A.J., Landman, K.A., Cooper-White, J.J. (2009) A cell migration device that maintains a defined surface with no cellular damage during wound edge generation. Lab on a Chip. 9: 2364-2369.
Parker, T., Upton, Z. & Leavesley, D.I. (2009) Vitronectin modulates human mesenchymal stem cell response to IGF-I and TGF-beta-1 in a serum-free environment. Tissue Engineering, 15 (6): 1415-1426.
Schleicher, I., Parker, A., Leavesley, D., Crawford, R., Upton, Z. & Xiao, Y. (2005) Surface modification by complexes of vitronectin and growth factors for serum-free culture of human osteoblasts. Tissue Engineering. 11: 1688-1698.
Parker, T., Upton, Z., Vellinga, D., Wei, M. & Leavesley, D.I. (2005) Potential pitfalls of radiolabel adsorption to ceramic biomaterials. Journal of Biomedical Materials Research, Part A. 72A:363-372.
