Mrs Sahar Keshvari

PhD

Post-doctoral research officer

Projects

Characterisation of adiponectin receptors

Understanding the Mechanism of Interleukin-22-therapy in Diabetes

About me

I graduated from Iran University of Medical Sciences in 2009 where I gained experience working in a medical setting within a diagnostic laboratory. I moved to Australia in early 2010 and completed a Master of Molecular Microbiology at Griffith University. In 2011 I undertook Honours at the Mater Medical Research Institute in the Metabolic Medicine Team headed by A/Prof Whitehead.I was awarded 1st class Honours for my project titled "Characterisation of the Adiponectin Receptors". Studies performed during my Honours were pivotal in defining that the two receptors for adiponectin, an anti-diabetic hormone, exhibit different subcellular localisation and provided the foundation for my first, first author publication, published in BBRC early 2013. My academic achievements have been recognised with several awards including an Academic Excellence Award from Griffith University and an Honours Scholarship and an Academic Award from the MMRI. I started my PhD in late 2012, continuing my investigations of the adiponectin receptors at the Mater Research Institute. My research has progressed significantly and the preliminary data I have generated forms the basis of an NHMRC project grant awarded in 2013.

Publications

  1. Keshvari S., Henstridge D.C., Ng C., Febbraio M.A., Whitehead J.P., Muscle-specific overexpression of AdipoR1 or AdipoR2 gives rise to common and discrete local effects whilst AdipoR2 promotes additional systemic effects. Scientific Reports, 2017.
  2. Kim Y.H. *, Barclay J.L. *, He J., Luo X., O'Neill H.M., Keshvari S., Webster J.A., Ng C., Hutley L.J., Prins J.B., and Whitehead J.P., Identification of carboxypeptidase X (CPX)-1 as a positive regulator of adipogenesis. FASEB J,2016.
  3. Barclay J.L.*, Keshvari, S.*, Whitehead J.P., Inder W.J., ANNALS EXPRESS: Development of an enzyme-linked immunosorbent assay for thrombospondin-1 and comparison of human plasma and serum concentrations. Ann Clin Biochem, 2016.
  4. Barclay J.L., Petersons C.J., Keshvari S, Sorbello J., Mangelsdorf B.L., Thompson C.H., Prins J.B., Burt M.G., Whitehead J.P., Inder W.J., Thrombospondin-1 is a glucocorticoid responsive protein in humans. Eur J Endocrinol, 2016. EJE-15-0964.
  5. Keshvari S. and Whitehead J.P., Characterisation of the adiponectin receptors: Differential cell-surface expression and temporal signaling profiles of AdipoR1 and AdipoR2 are regulated by the non-conserved N-terminal trunks. Mol Cell Endocrinol, 2015. 409: p. 121-9
  6. Yang M., Kimura, M., Ng C., He J., Keshvari S., Rose F. J., Barclay J. L., Whitehead J. P., Induction of heme-oxygenase-1 (HO-1) does not enhance adiponectin production in human adipocytes: Evidence against a direct HO-1 - Adiponectin axis. Mol Cell Endocrinol, 2015. 413: p. 209-216
  7. Keshvari S., Rose F. J., Charlton H. K., Scheiber N. L., Webster J., Kim Y. H., Ng C. Parton R. G., Whitehead J. P., Characterisation of the adiponectin receptors: The non-conserved N-terminal region of AdipoR2 prevents its expression at the cell-surface. Biochem Biophys Res Commun, 2013. 432(1): p. 28-33.

 

Research fields

Inflammatory Diseases Biology and Therapeutics