Dr. Md Moniruzzaman

B.Pharm (Hons.), M.Pharm (Pharmacology), PhD

Projects

Medicinal cannabis and inflammatory bowel diseases

About me

Dr Moniruzzaman was awarded his PhD from The University of Queensland (UQ) in 2020 and after undertaking a postdoc position at Mater Research Institute - UQ. Moniruzzaman's research focuses on diseases derived from chronic inflammation such as inflammatory bowel disease (IBD). Currently, his main focus is to understand the role of a small class of signalling proteins, known as cytokines, in the origin of these diseases. In particular, how they regulate key pathways like the oxidative and endoplasmic reticulum (ER) stress pathways and whether these pathways could be targeted to develop new therapies. In addition, he is also investigating whether modulation of the cannabinoid system by phytocannabinoids can improve disease pathology in IBD. His previous studies also involve the characterization of different natural products (plant extracts and isolated compounds) in management of acute pain, inflammation and associated diseases which also enabled him to publish more than 10 articles in different prestigious journals.

Moniruzzaman has completed his B.Pharm (Hons.) degree from Stamford University in Bangladesh with several awards for his academic excellence. He also received a full-funded scholarship (SRD-II) for his Master degree (M.Pharm) from Dongguk University, Republic of Korea. Later on, he received the Research Training Program Scholarship (previously known as IPRS) and UQ Centennial Scholarship (UQCent) from The University of Queensland, Australia for his PhD study. He is also receiving Frank Clair Scholarship from Mater Research as an appreciation of his academic excellence.

“I started a career in biomedical research because of my deep curiosity about the way in which the human body works. Now, I am working to understand the contribution of different cytokines in human pathology, which will allow me to devise the causes behind the origin of inflammatory diseases and develop effective therapies to serve the community.”

Scholarships and awards:

  • Jan 2022 - Dec 2022: UQ Postdoctoral Research Fellowship
  • July 2021 - June 2022: UQ Postdoctoral Research Fellowship
  • Jan 2017 - Dec 2019: Research Training Program (RTP) Scholarship.
  • Dec 2016 - Aug 2019: Frank Clair Scholarship.
  • Jan 2016 - Aug 2019: University of Queensland Centennial (UQCent) Scholarship for Ph.D. candidature.
  • Jan 2016 - Dec 2016: International Postgraduate Research Scholarship (IPRS).
  • Sept 2013 - Aug 2015: SRD II scholarship for MS, Dongguk University, Republic of Korea.
  • July 2011 - Dec 2011 (Summer Semester): Academic scholarship, Stamford University Bangladesh.
  • July 2010 - Dec 2010 (Summer Semester): Academic scholarship, Stamford University Bangladesh.
  • Jan 2010 - June 2010 (Spring Semester): Academic scholarship, Stamford University Bangladesh.

Society affiliations:

  • July 2021 - continue: Member, QLD-ASI committee
  • Aug 2017 - continue: Member, Australasian Society for Immunology (ASI).
  • May 2017 - continue: Member, Australian Society for Medical Research (ASMR).
  • Mar 2015 – Aug 2015: Member, Pharmaceutical Society of Korea (PSK).
  • Sept 2014 – Feb 2015: Member, Pharmaceutical Society of Korea (PSK).
  • Mar 2014 – Aug 2014: Member, Pharmaceutical Society of Korea (PSK).
  • July 2012: Lifetime member of Stamford Pharmacy Alumni Association (SPAA), Bangladesh.

Publications

List of recent publications:

  1. Naisarg Pujara, Kuan Yau Wong, Zhi Qu, Ran Wang, Md. Moniruzzaman, Prarthana Rewatkar, Tushar Kumeria, Benjamin P Ross, Michael McGuckin*, Amirali Popat*. 2020. Oral delivery of β-lactoglobulin-nanosphere-encapsulated resveratrol alleviates inflammation in Winnie mice with spontaneous ulcerative colitis. Molecular Pharmaceutics, (In Press), doi:10.1021/acs.molpharmaceut.0c00048 [PubMed]
  2. Afia Ferdous, Rabir Ahmed Janta, Rubaiya Nushin Arpa, Mirola Afroze, Mala Khan, Md. Moniruzzaman*. 2020. The leaves of Bougainvillea spectabilis suppressed inflammation and nociception in vivo through the modulation of glutamatergic, cGMP, and ATP-sensitive K + channel pathways. Journal of Ethnopharmacology (The official journal of the International Society for Ethnopharmacology), 261:113148. doi:10.1016/j.jep.2020.113148 [PubMed]
  3. Md. Moniruzzaman, Ran Wang, Varinder Jeet, Michael A McGuckin, Sumaira Z Hasnain*. 2019. Interleukin (IL)-22 from IL-20 subfamily of cytokines induces colonic epithelial cell proliferation predominantly through ERK1/2 pathway. International Journal of Molecilar Sciences, 20(14):3468, doi:10.3390/ijms20143468 [PubMed]
  4. Md. Moniruzzaman*, Md Abdul Mannan, Md Farhad Hossen Khan, Ariful Basher Abir, Mirola Afroze. 2018. The leaves of Crataeva nurvala Buch-Ham. modulate locomotor and anxiety behaviors possibly through GABAergic system. BMC Complementary and Alternative Medicine. 14: 354. (Affiliated with the International Society for Complementary Medicine Research), doi:10.1186/s12906-018-2338-y [PubMed]
  5. Md. Moniruzzaman*, Young-Won Chin, Jungsook Cho*. 2018. HO-1 dependent antioxidant effects of ethyl acetate fraction from Physalis alkekengi fruit ameliorates scopolamine-induced cognitive impairments. Cell Stress and Chaperones, 23(4):763-772. (The official journal of the Cell Stress Society International), doi: 10.1007/s12192-018-0887-0 [PubMed]
  6. Ran Wang, Md. Moniruzzaman, Eric Shuffle, Rohan Lourie, Sumaira Z Hasnain*. 2018. Immune regulation of the unfolded protein response at the mucosal barrier in viral infection. Clinical & Translational Immunology, 7(4): e1014. (The official journal of the Australasian Society for Immunology), doi: 10.1002/cti2.1014 [PubMed]
  7. Md. Moniruzzaman, Shambhunath Bose, Young-Mi Kim, Young-Won Chin, Jungsook Cho*. 2016. The ethyl-acetate fraction from Physalis alkekengi fruit inhibits LPS-induced pro-inflammatory mediators in BV2 cells and inflammatory pain in mice. Journal of Ethnopharmacology. 181: 26–36. (The official journal of the International Society for Ethnopharmacology), doi:10.1016/j.jep.2016.01.023 [PubMed]
  8. Shambhunath Bose, Sunyoung Kim, Yeonsoo Oh, Md. Moniruzzaman, Gyeongjun Lee, Jungsook Cho*. 2016. Effect of CCL2 on BV2 microglial cell migration: Involvement of probable signaling pathways. Cytokine. 81: 39–49. (The official journal of the International Cytokine and Interferon Society), doi:10.1016/j.cyto.2016.02.001 [PubMed]
  9. Nushrat Sharmin Ani, Sudip Chakraborty, Md. Moniruzzaman*. 2016. The methanolic extract from Murraya koenigii L. inhibits glutamate-induced pain and involves ATP-sensitive K+ channel as antinociceptive mechanism. Advances in Pharmacological Sciences. Article ID 3790860, 2016: 1-6. doi:10.1155/2016/379086 [PubMed]
  10. Md. Moniruzzaman*, Md. Sarwar Hossain, Partha Sharoti Bhattacharjee. 2016. Evaluation of antinociceptive activity of methanolic extract of leaves of Stephania japonica Linn. Journal of Ethnopharmacology. 186: 205-208. (The official journal of the International Society for Ethnopharmacology),  doi:10.1016/j.jep.2016.04.008 [PubMed]
  11. Md. Moniruzzaman*, Partha Sharoti Bhattacharjee, Moushumi Rahman Pretty, Md. Sarwar Hossain. 2016. Sedative and anxiolytic-like actions of ethanol extract of leaves of Glinus oppositifolius (Linn.) Aug. DC. Evidence-Based Complementary and Alternative Medicine. Article ID 8541017, 2016: 1-8. doi:10.1155/2016/8541017 [PubMed]
  12. Md. Moniruzzaman, Gyeongjun Lee, Shambhunath Bose, Minho Choi, Heeson Lee, Jungsook Cho*. 2015. Antioxidant and anti-inflammatory effect of N-((3, 4-dihydro-2H-benzo[h]chromen-2-yl)methyl)-4-methoxyaniline in LPS-induced BV2 microglial cells. Biological and Pharmaceutical Bulletin. 38(12): 1831-1835. (The official journal of the Pharmaceutical Society of Japan), doi:10.1248/bpb.b15-00473 [PubMed]
  13. Md. Moniruzzaman, Ambia Khatun, Mohammad Zafar Imam*. 2015. Evaluation of antinociceptive activity of ethanol extract of leaves of Adenanthera pavonina. Evidence-Based Complementary and Alternative Medicine. Article ID 412497, 2015: 1-8. doi:10.1155/2015/412497 [PubMed]
  14. Md. Moniruzzaman*, Afia Ferdous, Fatama Wahid Bokul. 2015. Evaluation of antinociceptive activity of ethanol extract of bark of Polyalthia longifolia. Journal of Ethnopharmacology. 172: 364-367. (The official journal of the International Society for Ethnopharmacology), doi:10.1016/j.jep.2015.06.053 [PubMed]
  15. Md. Moniruzzaman*, Md. Atikur Rahman, Afia Ferdous. 2015. Evaluation of sedative and hypnotic activity of ethanolic extract of Scoparia dulcis Linn. Evidence-Based Complementary and Alternative Medicine. Article ID 873954, 2015: 1-6. doi:10.1155/2015/873954 [PubMed]
  16. Md. Moniruzzaman*, Afia Ferdous, Shamima Irin. 2015. Evaluation of antinociceprive activity of ethanol extract of Hedyotis corymbosa Linn. whole plant in mice. Journal of Ethnopharmacology. 161: 82-85. (The official journal of the International Society for Ethnopharmacology), doi:10.1016/j.jep.2014.12.011 [PubMed]
  17. Md. Moniruzzaman, Mohammad Zafar Imam*. 2014. Evaluation of antinociceptive effect of methanolic extract of leaves of Crataeva nurvala Buch.-Ham. BMC Complementary and Alternative Medicine. 14: 354. (Affiliated with the International Society for Complementary Medicine Research), doi:10.1186/1472-6882-14-354 [PubMed]
  18. Mohammad Zafar Imam*, Md. Moniruzzaman. 2014. Antinociceptive effect of ethanol extract of leaves of Lannea coromandelica. Journal of Ethnopharmacology. 154: 109-115. (The official journal of the International Society for Ethnopharmacology), doi:10.1016/j.jep.2014.03.032 [PubMed]
  19. Afia Ferdous*, Rifatus-sana Anwar, Md. Moniruzzaman, Anjan Chakraborti. 2012. Evaluation of analgesic and neuropharmacological activity of methanolic extract of Nyctanthes arbor-tristis Linn. Stamford Journal of Pharmaceutical Sciences. 5 (1-2): 35-40. (Print Version). [ResearchGate]

 

Conference posters/talks:

  1. Md. Moniruzzaman, Ran Wang, Maya Patrick, Cora Lau, Varinder Jeet, Michael A McGuckin, Sumaira Z Hasnain*. 29th November 2017. IL-22 as a potential therapy to boost mucosal wound healing in the lung. 46th Annual Scientific Meeting of the Australasian Society for Immunology. Brisbane Convention & Exhibition Centre, Brisbane, Australia.
  2. Md. Moniruzzaman, Ran Wang, Saba Farnaghi, Varinder Jeet, Michael A McGuckin, Sumaira Z Hasnain*. 17th August 2017. Mucosal healing: Role of IL-20 subfamily cytokines in cell proliferation with their underlying mechanism(s). 17th Brisbane Immunology Group Annual Retreat. Victoria Park Golf Complex, Brisbane, Australia.
  3. Md. Moniruzzaman, Ran Wang, Maya Patrick, Cora Lau, Michael A McGuckin, Sumaira Z Hasnain*. 1-4th August 2017. 57th PA Hospital Health Symposium. Intranasal instillation of bleomycin: The most suitable and non-invasive technique to induce lung fibrosis.  Princess Alexandra Hospital, Brisbane, Australia.
  4. Md. Moniruzzaman, Ran Wang, Maya Patrick, Cora Lau, Michael A McGuckin, Sumaira Z Hasnain*. 31st July 2017. Translational Research Institute Student Symposium. Intranasal instillation of bleomycin: The most suitable and non-invasive technique to induce lung fibrosis.  Translational Research Institute, Brisbane, Australia.
  5. Md. Moniruzzaman, Ran Wang, Saba Farnaghi, Varinder Jeet, Michael A McGuckin, Sumaira Z Hasnain*. 31st May 2017. Mucosal healing: Role of IL-20 subfamily cytokines in cell proliferation with their underlying mechanism(s). QLD ASMR Postgraduate Student Conference. Translational Research Institute, Brisbane, Australia.
  6. Md. Moniruzzaman. 12th May 2017. Comparison of two murine models of bleomycin-induced pulmonary fibrosis. TRI Friday Seminar. Translational Research Institute, Brisbane, Australia.
  7. Md. Moniruzzaman, Jennifer R. Deuis, Irina Vetter*. 13th July 2016. Discovery and characterization of novel sodium channel modulators using high throughput approaches. IMB RHD Student Symposium. Bioscience Precinct, The University of Queensland.
  8. Mirola Afroze*, Md. Moniruzzaman, Mohammad Zafar Imam, Abdul Ghani. 16th March, 2016. Phytochemical and pharmacological evaluation of a new herbal antacid formulation. 16th Asian Chemical Congress. Pan Pacific Sonargaon Dhaka. Section MN-PP-10.
  9. Mirola Afroze*, Md. Moniruzzaman, Mohammad Zafar Imam, Tanvir Ahmed Siddiquee, Abdul Ghani. 5th March, 2016. Evaluation of chemico-pharmacological properties of a new polyherbal unani formulation. 4th AYUNS International Conference. Nabab Nawab Ali Chowdhury Senate Hall. Volume 3(1):47.
  10. Md. Moniruzzaman, Youngwon Chin, Jungsook Cho*. 24th April, 2015. Ethyl acetate fraction from Physalis alkekengi fruit exerts potent antioxidant effects through Nrf-2/HO-1 pathway in BV2 microglial cells. Spring International Convention of the Pharmaceutical Society of Korea. OSONG Medical Innovation Foundation C&V Center. Section P1-104.
  11. Md. Moniruzzaman, Gyeongjun Lee, Shambhunath Bose, Minho Choi, Heesoon Lee, Jungsook Cho*. 24th April, 2015. Antioxidant and anti-inflammatory activity of N-((3,4-dihydro-2H-benzo[h]chromen-2-yl)methyl)-4-methoxyaniline in LPS-induced BV2 microglial cells. Spring International Convention of the Pharmaceutical Society of Korea. OSONG Medical Innovation Foundation C&V Center. Section P1-132.
  12. Md. Moniruzzaman, Shambhunath Bose, Young-Won Chin, Jungsook Cho*. 25th October 2014. Anti-inflammatory effects of Physalis alkekengi fruit through inhibition of PI3K/Akt and MAP Kinase pathways in LPS-induced BV2 microglial cells. Fall International Convention of the Pharmaceutical Society of Korea. Hotel Hyundai, Section P1-30.
  13. Md. Moniruzzaman, Mohammad Zafar Imam*. 18th April 2014. Antinociceptive effect of ethanol extract of leaves of Lannea coromandelica. Spring International Convention of the Pharmaceutical Society of Korea. The-K Seoul Hotel. Section P1-14.

Research fields

Immunology

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