Dr. Kelvin Zewen Tuong

BBiomedSc, PhD

Post-Doctoral Research Fellow

    Projects

    Gene expression profiling of dendritic cells during HPV-related cancer development using bulk and single-cell RNA-sequencing analysis

    About me

    Dr Kelvin Tuong completed his PhD in the laboratories of Professor Jennifer Stow and Professor George Muscat in the Institute for Molecular Bioscience (IMB) at The University of Queensland. His PhD research topic revolved around the nuclear hormone receptor RORα and its role in fat/lipid metabolism in the context of obesity and diabetes. Specifically, he investigated the role of this nuclear receptor in governing macrophage function, adipose tissue fat metabolism and liver homeostatsis. Overall, Dr Tuong’s doctoral studies provided new evidence to support the role for RORα and oxysterol signaling as critical components in regulating metabolism and immunity.

    Dr Kelvin Tuong is currently undertaking post-doctoral training in laboratory of Professor Ian Frazer where he is conducting studies looking into factors that influence HPV-related cancer development and skin cancer development using molecular cell biology, immunology and next-generation sequencing approaches. He is particularly interested in how antigen presenting cells control the immunological dynamics within a cancer-like microenvironment and how that can be translated for better design towards effective immunotherapy.

    Publications

    Zhussupbekova, Samal, Sinha, Rohit, Kuo, Paula, Lambert, Paul F., Frazer, Ian H. and Tuong, Zewen Kelvin. (2016) A Mouse Model of Hyperproliferative Human Epithelium Validated by Keratin Profiling Shows an Aberrant Cytoskeletal Response to Injury​. EBioMedicine, 9 314-323. doi:10.1016/j.ebiom.2016.06.011

    Tuong, Zewen Kelvin, Fitzsimmons, Rebecca, Wang, Shu-Ching Mary, Oh, Tae Gyu, Lau, Patrick, Steyn, Frederik, Thomas, Gethin and Muscat, George E. O. (2016) Transgenic adipose-specific expression of the nuclear receptor RORα drives a striking shift in fat distribution and impairs glycemic control. EBioMedicine11 101-117. doi:10.1016/j.ebiom.2016.08.027

    Goode, Joel M., Pearen, Michael A., Tuong, Zewen K., Wang, Shu-Ching M., Oh, Tae Gyu, Shao, Emily X. and Muscat, George E. (2016) The nuclear receptor, Nor-1, induces the physiological responses associated with excercise.Molecular Endocrinology30 6: 660-676. doi:10.1210/me.2015-1300

    Tuong, Zewen Kelvin, Lau, Patrick, Du, Ximing, Condon, Nicholas D., Goode, Joel M., Oh, Tae Gyu, Yeo, Jeremy C., Muscat, George E. O. and Stow, Jennifer L. (2016) RORα and 25-hydroxycholesterol crosstalk regulates lipid droplet homeostasis in macrophages. PLoS ONE11 1: . doi:10.1371/journal.pone.0147179

    Lau, Patrick, Tuong, Zewen K., Wang, Shu-Ching, Fitzsimmons, Rebecca L., Goode, Joel M., Thomas, Gethin P., Cowin, Gary J., Pearen, Michael A., Mardon, Karine, Stow, Jennifer L. and Muscat, George E. O. (2015) Ror-alpha deficiency and decreased adiposity are associated with induction of thermogenic gene expression in subcutaneous white and brown adipose tissue. American Journal of Physiology: Endocrinology and Metabolism308 2: E159-E171. doi:10.1152/ajpendo.00056.2014

    Pearen, Michael A., Goode, Joel M., Fitzsimmons, Rebecca L., Eriksson, Natalie A., Thomas, Gethin P., Cowin, Gary J., Wang, S.-C. Mary, Tuong, Zewen K. and Muscat, George E. O. (2013) Muscle specific Nor-1 expression regulates multiple pathways that effect adiposity, metabolism and endurance. Molecular Endocrinology27 11: 1897-1917. doi:10.1210/me.2013-1205

    Tuong, Zewen K., Lau, Patrick, Yeo, Jeremy C., Pearen, Michael A., Wall, Adam A., Stanley, Amanda C., Stow, Jennifer L. and Muscat, George E. O. (2013) Disruption of Rorα1 and cholesterol 25-hydroxylase expression attenuates phagocytosis in male Rorαsg/sg mice. Endocrinology154 1: 140-149. doi:10.1210/en.2012-1889

    Research fields

    Skin Cancer, Immunotherapy