Professor John Upham

MB BS FRACP PhD

Group Leader, Lung & Allergy Research and Chair, Metro South Research

Projects

Anti-viral immunity in severe asthma

Immunity to non-typeable Haemophilus influenzae in early childhood

Influenza vaccination in COPD

Immunity to viruses in people with asthma and other chronic lung diseases, causes of recurrent lung infections in Indigenous & non-Indigenous children, clinical trials of novel asthma treatments

About me

John Upham is a clinical scientist and respiratory physician with longstanding research interests in the immunological basis of airway inflammation, and the development of novel approaches to treatment. He has published over 180 peer-reviewed journal articles and book chapters, has been cited over 5400 times and has an 'H index' of 39. The majority of his publications are in the higher impact journals in the field.

He is a previous recipient of an NHMRC Neil Hamilton Fairley Fellowship, and the Young Investigator Award, Thoracic Society of Australia & New Zealand (TSANZ). He has been a long term recipient of funding from the NHMRC,inclduing Practitioner Fellowships, Program & Project Grants, a Development Grant and a CRE for Indigenous Lung Health.

Current projects include anti-viral immunity in severe asthma: roles of TLR7 and plasmacytoid dendritic cells; pathogenesis of protracted bacterial bronchitis in children; randomised trial of low dose azithromycin in severe asthma; genetic regulation of anti-viral immunity; influenza vaccination in chronic lung disease, and how this might be modified by diet and the gut microbiome.

After specialist training in Brisbane, John completed a PhD at the University of Western Australia, and spent 2 years in Canada, before moving back to Perth in 1998. In 2007, he moved to Brisbane to take up a position as Professor of Respiratory Medicine. He is based at the Princess Alexandra Hospital and the Translational Research Institute, and is the academic head of the Discipline of Medicine within PA/Southside School of Medicine, University of Queensland, and the Chair of Metro South Research

John is married to Susan and has 4 daughters. Outside of work he enjoys cycling, reading and bushwalking.

Publications

  1. Roponen M, Yerkovich ST, Hollams E, Sly PD, Holt PG, Upham JW. Toll-like receptor 7 function is reduced in adolescents with asthma. Eur Respir J 2010; 35:64-71. 
  2. Reddel HK, Upham JW, Salvi SS, Yang IA. “Year-in-Review: Asthma, COPD & Airway Biology” Respirology 2010; 15:365-76. 
  3. Sturges N, Wikström ME, Winfield KR, Gard SE, Brennan S, Sly PD & Upham JW. Monocytes from children with cystic fibrosis show enhanced expression of Toll-like receptor 4. Pediatric Pulmonology 2010; 45(9):883-9. 
  4. Pizzutto, S.J., Upham, J.W., Yerkovich, S.T., Chang, A.B. Inhaled non-steroid anti-inflammatories for children and adults with bronchiectasis. Cochrane Database of Systematic Reviews April 2010; 4:CD007525. 
  5. Upham JW, Pritchard A. Are rhinoviral proteinases responsible for mixed Th1 and Th2 immunity in chronic obstructive pulmonary disease? J Allergy Clin Immunol. 2010 Dec; 126(6):1318. 
  6. *Strickland DH, *Upham JW, Holt PG. (*equal first authors) Epithelial-dendritic cell interactions in allergic disorders. Current Opinion in Immunology 2010 Dec; 22(6):789-94. 
  7. Carroll ML, Yerkovich ST, Pritchard AL, Davies JM, Upham JW. Adaptive immunity to rhinoviruses: sex and age matter. Respiratory Research 2010 Dec 31; 11(1):184. 
  8. *Smith DJ, *Yerkovich ST, Towers MA, Carroll ML, Thomas R, Upham JW. (*equal first authors). Reduced soluble receptor for advanced glycation end products in chronic obstructive pulmonary disease. European Respir J 2011; 37:516-522. 
  9. Davies JM, Dang TD, Drew AC, Voskamp A, Biondo M, Phung M, Upham JW, Rolland JM, O'Hehir RE. Functional IgE cross-reactivity between Pas n 1 of Bahia grass pollen and other group 1 grass pollen allergens. Clin Exp Allergy 2011 Feb; 41(2):281-91. 
  10. Upham JW, James AL. Remission of asthma: the next therapeutic frontier? Pharmacology & Therapeutics 2011; 130:38-45. 
  11. Davies JM, Voskamp A, Dang TD, Pettit B, Loo D, Petersen A, Hill MM, Upham JW, Rolland JM, O'Hehir RE The dominant 55 kDa allergen of the subtropical Bahia grass (Paspalum notatum) pollen is a group 13 pollen allergen, Pas n 13. Molecular Immunol. 2011; 48:931-40. 
  12. Wurzel D, Marchant JM, Yerkovich ST, Upham JW, Masters IB, Chang AB. Short courses of antibiotics for children and adults with bronchiectasis (Review). Cochrane Database Syst Rev. 2011 Jun 15; 6: CD008695. 
  13. Yerkovich ST, Upham JW. “Interactions between allergens and DC: pattern recognition receptors and their function in the pathogenesis of allergic respiratory diseases”. Chapter in Allergens and respiratory pollutants: therole of innate immunity. Pages 245-265. Edited by Marc Williams; published by Biohealthcare Publishing (Oxford) Ltd, Oxford UK. Published 18th July 2011. ISBN 9781907568541. 
  14. Upham JW, Smith DJ, Yerkovich ST. Correspondence: Does RAGE protect smokers from COPD? European Respir J 2011; 38: 744. 
  15. Cheng AC, Kotsimbos T, Kelly HA, Irving LB, Bowler SD, Brown SG, Holmes M, Jenkins CR, Thompson P, Simpson G, Wood-Baker R, Senanayake SN, Brady SJ, Paterson DL, Wark PA, Upham JW et al. Effectiveness of H1N1/09 monovalent and trivalent influenza vaccines against hospitalization with laboratory-confirmed H1N1/09 influenza in Australia: a test-negative case control study. Vaccine 2011;29: 7320-7325. 
  16. Davies JM, Carroll ML, Li H, Poh AM, Kirkegard D, Towers M, Upham JW. Budesonide and formoterol reduce early innate anti-viral immune responses in vitro. PLoS ONE 2011; 6(11): e27898. 
  17. Clifford HD, Yerkovich ST, Khoo SK, Zhang G, Upham J, Le Souëf PN, Richmond P, Hayden CM. Toll-like receptor 7 and 8 polymorphisms: associations with functional effects and cellular and antibody responses to measles virus and vaccine. Immunogenetics. 2012; 64(3):219-28. 
  18. Yerkovich ST, Chang AB, Carroll ML, Petsky HL, Scrivener G, Upham JW. Soluble receptor for advanced glycation end products (sRAGE) is present at high concentrations in the lungs of children and varies with age and the pattern of lung inflammation Respirology 2012 Jul;17:841-6. doi: 10.1111/j.1440-1843.2012.02174.x. 
  19. Davies JM, Li H, Green M, Towers M and Upham JW. Subtropical grass pollen allergens are important for allergic respiratory diseases in subtropical regions. Clin Transl Allergy. 2012 Mar 5;2(1):4. 
  20. Clifford HD, Yerkovich ST, Khoo SK, Zhang G, Upham J, Le Souëf PN, Richmond P, Hayden CM. TLR3 and RIG-I gene variants: associations with functional effects on receptor expression and responses to measles virus and vaccine in vaccinated infants. Human Immunol 2012 Jun;73(6):677-85. 
  21. Pritchard AL, Carroll ML, Burel JG, Phipps S, Upham JW. Innate interferons and plasmacytoid dendritic cells constrain TH2 cytokine responses to rhinovirus: a regulatory mechanism with relevance to asthma. J Immunology 2012;188(12):5898-905. 
  22. Chang AB, Yerkovich ST, Gibson PG, Anderson-James S, Petsky HL, Carroll ML, Masters IB, Marchant J, Wurzel D, Upham JW. Pulmonary innate immunity in children with protracted bacterial bronchitis. J Pediatrics 2012; 161(4):621-625.e1. doi: 10.1016/j.jpeds.2012.03.049. 
  23. Pritchard AL, White OJ, Burel JG, Upham JW. Innate interferons inhibit allergen and microbial specific TH2 responses. Immunol Cell Biol. 2012; 90:974-7. doi: 10.1038/icb.2012.39. 
  24. Yerkovich ST, Hales BJ, Carroll ML, Towers MA, Smith DJ, Thomas WR, Upham JW. Reduced rhinovirus-specific antibodies are associated with acute exacerbations of chronic obstructive pulmonary disease requiring hospitalisation. BMC Pulmonary Medicine. 2012 Jul 31;12(1):37. doi: 10.1186/1471-2466-12-37 
  25. Rate A, Bosco A, McKenna KL, Holt PG, Upham JW. Airway epithelial cells condition dendritic cells to express multiple immune surveillance genes. PLoS One 2012; 7(9): e44941. doi:10.1371/journal.pone.0044941. 
  26. Burel JG, Nath K, Pritchard AL, Towers M, Looke D, Davies JM, Upham JW. Evaluation of immune responses to influenza vaccination in chronic obstructive pulmonary disease. Journal of Vaccines & Vaccination 2013 doi: 10.4172/2157-7560.S4-001
  27. Pizzuto SJ, Grimwood K, Bauert P, Schutz KL, Yerkovich ST, Upham JW, Chang AB. Bronchoscopy contributes to the clinical management of indigenous children newly diagnosed with bronchiectasis. Pediatric Pulmonology 2013; 48:67–73; doi: 10.1002/ppul.22544. 
  28. Simpson JL, Gibson PG, Yang IA, Upham J, James AL, Reynolds PN, Hodge S. Impaired macrophage phagocytosis in non-eosinophilic asthma. Clin Exp Allergy 2013; 43: 29–35. DOI: 10.1111/j.1365-2222.2012.04075.x 
  29. Liu X, Jin L, Upham JW, Roberts M. The development of models for the evaluation of pulmonary drug disposition (review). Expert Opin Drug Metab Toxicol. 2013 Apr;9(4):487-505. doi: 10.1517/17425255.2013.754009. PMID 23294005 
  30. Wurzell DF, Marchant JM, Masters B, Yerkovich ST, Upham JW, Chang AB. Wet cough in children: infective and inflammatory characteristics in broncho-alveolar lavage fluid. Pediatric Pulmonology 2014 Jun; 49:561-8. doi: 10.1002/ppul.22792. Epub 2013 Jun 20. PMID: 23788413 
  31. Cheng AC, Holmes M, Irving LB, Brown SGA, Waterer GW, Korman TM; Friedman D, Senanayake S, Dwyer D, Brady S, Simpson G, Wood-Baker R, Upham JW et al. Influenza vaccine effectiveness against hospitalisation with confirmed influenza in the 2010-11 seasons: a test-negative observational study. PLoS One 2013 8(7): e68760. doi: 10.1371/journal.pone. 0068760. PMID:23874754 
  32. Wurzell DF, Marchant JM, Clark JE, Mackay IM, Wang CY, Sloots TP, Upham JW, Yerkovich ST, Masters IB, Baker PJ, Anderson-James S, Chang AB. Respiratory virus detection in nasopharyngeal aspirate versus bronchoalveolar lavage is dependent on virus type in children with chronic respiratory symptoms. J Clin Virology 2013 Dec; 58(4):683-8. doi: 10.1016/j.jcv.2013.09.016. PMID: 24125830 
  33. Georas SN, Upham JW. Environmental exposures and innate immunity in the lung. J Environ Immunol Toxicol 2014 Jan;2(1):1-3. PMID: 24839593 
  34. Lynch JP, Mazzone SB, Rogers MJ, Arikkatt JJ, Loh Z, Pritchard AL, Upham JW, Phipps S. The plasmacytoid dendritic cell: a cell at the cross-roads in asthma (review). Eur Respir J 2014 Jan;43(1):264-75. doi: 10.1183/09031936.00203412. PMID: 23429916 
  35. Nath KD, Burel JG, Shankar V, Pritchard AL, Towers M, Looke D, Davies JM, Upham JW. Clinical factors associated with the humoral immune response to influenza vaccination in chronic obstructive pulmonary disease. Int J COPD 2014; 9: 51–56. http://dx.doi.org/10.2147/COPD.S53590    PMID:24399872 
  36. Simpson JL, Gibson PG, Yang IA, Upham JW, James AL, Reynolds PN, Hodge S. Altered sputum granzyme B and granzyme B/proteinase inhibitor-9 in patients with non-eosinophilic asthma. Respirology 2013; 19: 280–287. doi: 10.1111/resp.12213. PMID: 24372772 
  37. Cheng AC, Holmes M, Irving LB, Brown SGA, Waterer GW, Korman TM; Friedman D, Senanayake S, Dwyer D, Brady S, Simpson G, Wood-Baker R, Upham JW et al. Influenza epidemiology, vaccine coverage and vaccine effectiveness in sentinel Australian hospitals in 2012: the Influenza Complications Alert Network (FluCAN). Commun Dis Intell Q Rep. 2013 Sep 30;37(3):E246-52. PMID: 24890961 
  38. Wurzel DF, Marchant JM, Yerkovich ST, Upham JW, Mackay IM, Masters IB, Chang AB. Prospective Characterisation of Protracted Bacterial Bronchitis (PBB) in Children. Chest 2014 Jun 1;145(6):1271-8. doi: 10.1378/chest.13-2442. PubMed PMID:24435356. 
  39. Wurzel DF, Mackay IM, Marchant JM, Wang, Yerkovich ST, Upham JW, Smith-Vaughan H, Petsky H, Chang AB. Adenovirus Species C is associated with chronic suppurative lung diseases in children. Clin Infect Dis. 2014 Apr 18.[Epub ahead of print] PubMed PMID: 24748519. 
  40. Baines KJ, Upham JW, Yerkovich ST, Chang AB; Marchant JM, Carroll M, Simpson JL, Gibson PG. Mediators of neutrophil function in children with protracted bacterial bronchitis. Chest 2014 May 29. doi: 10.1378/chest.14-0131. [Epub ahead of print] PubMed PMID: 24874501 
  41. Spann KM, Loh Z, Lynch JP, Ullah A, Zhang V, Baturcam E, Werder RB, Khajornjiraphan N, Rudd P, Loo YM, Suhrbier A, Gale M Jr, Upham JW, Phipps S. IRF-3, IRF-7, and IPS-1 Promote Host Defense against Acute Human Metapneumovirus Infection in Neonatal Mice. Am J Pathol. 2014 Apr 10. doi: 10.1016/j.ajpath.2014.02.026. PubMed PMID: 24726644. 
  42. Zhang, Xiao-yan; Simpson J; Yang I; Upham JW; Reynolds P; Hodge S; James, A; Jenkins, C; Peters, M; Lin, J; Gibson, PG. Full blood count parameters for the detection of asthma inflammatory phenotypes Clin Exp Allergy 2014 Sep;44(9):1137-45. doi:10.1111/cea.12345 PubMed PMID: 24849076. 
  43. Pizzutto SJ, Yerkovich ST, Upham JW, Hales BJ, Thomas WR, Chang AB. Children with chronic suppurative lung disease have a reduced capacity to synthesize interferon-gamma in vitro in response to non-typeable Haemophilus influenzae. PLoS ONE 2014; vol 9(8): e104236. doi:10.1371/journal.pone.0104236. PMID: 25111142 
  44. Cheng AC, Dwyer DE, Holmes M, Irving LB, Brown SGA, Waterer GW, Korman TM, Hunter C, Hewagama S, Friedman ND, Wark PA, Simpson G, Upham JW et al. Influenza epidemiology, vaccine coverage and vaccine effectiveness in sentinel Australian hospitals in 2013: the Influenza Complications Alert Network. Commun Dis Intell 2014; 38(2):E143–E149. 
  45. Pritchard A, White O, Burel J, Carroll M, Phipps S, Upham JW. Asthma is associated with multiple alterations in anti-viral type I IFN signalling pathways. PLoS ONE 2014 Sep 9;9(9):e106501. doi: 10.1371/journal.pone.0106501. PMID 25203745. 
  46. Timbrell V., Riebelt L., Simmonds C., Solley G., Smith W., Mclean-Tooke A., van Nunen S., Smith P., Upham J., Langguth D., Davies J. An immunodiagnostic assay for quantitation of specific IgE to the major pollen allergen component, Pas n 1, of the subtropical Bahia grass. Int Arch Allergy Immunol 2014 2014;165(4):219-28. doi:10.1159/000369341. PubMed PMID: 25612605 
  47. Wong K, Timbrell V, Towers M, Collins T, Upham JW, Collins A and Davies JM. IgE+ B cells are scarce but allergen-specific B cells with a memory phenotype circulate in patients with allergic rhinitis. Allergy 2015 Apr;70(4):420-8 
  48. Pizzutto SJ, Yerkovich ST, Upham JW, Hales BJ, Thomas WR, Chang Anne B. Improving immunity to Haemophilus in children with suppurative lung disease. Vaccine 2015 Jan 3;33(2):321-6. doi: 10.1016/j.vaccine.2014.11.024.2014 PMID: 25448103 
  49. Gao P, Gibson PG, Baines KJ, Yang IA, Upham JW, Reynolds PN, Hodge S, James AL, Jenkins C, Peters MJ, Zhang J, Simpson JL. Anti-inflammatory deficiencies in neutrophilic asthma: reduced galectin-3 and IL-1RA/IL-1ß. Respir Res. 2015 Jan 24;16(1):5. PMID: 25616863. 
  50. Chang AB, Marsh RL, Upham JW, Hoffman LR, Smith-Vaughan H, Holt D, Toombs M, Byrnes CA, Yerkovich ST, Torzillo P, O’Grady KF, Grimwood K. Towards making inroads in reducing the disparity of lung health in Australian Indigenous and New Zealand Māori children. Frontiers in Pediatrics 2015 Feb 13;3:9. doi: 10.3389/fped.2015.00009 
  51. Scott H, Latham JR, Callister R, Pretto JJ, Baines K, Saltos N, Upham JW, Wood LG. Acute exercise is associated with reduced exhaled nitric oxide in physically inactive adults with asthma. Annals of Allergy, Asthma & Immunology 2015 Jun; 114(6):470-9. PMID 25935433 
  52. Pizzutto SJ, Upham JW, Yerkovich ST, Chang AB High pulmonary levels of IL-6 and IL-1β in children with chronic suppurative lung disease are associated with low systemic IFN-γ production in response to non-typeable Haemophilus influenzae” PLoS ONE 2015 Jun 12;10(6):e0129517. doi: 10.1371/journal.pone.0129517 PMID 26066058 
  53. Chang AB, Grimwood K, Gibson PG, Upham JW. Protracted bacterial bronchitis (PBB): Definition, mechanisms and treatment. Lancet Respiratory Medicine 2015 Oct; 3(10):743-4. PMID: 26297667 
  54. Hodge G, Upham JW, Chang AB, Baines KJ, Yerkovich ST, Pizzutto SJ, Hodge S. Increased peripheral blood pro-inflammatory/cytotoxic lymphocytes in children with bronchiectasis. PLoS ONE 2015 Aug 10;10(8):e0133695. PMID: 26258716 
  55. Xi Y, Finlayson A, White OJ, Carroll ML, Upham JW. Rhinovirus stimulated IFN-α production: how important are plasmacytoid DCs, monocytes and endosomal pH? Clin Transl Immunology. 2015 Oct 30;4(10):e46. PMID: 26682054. 
  56. Hodge S, Hodge G, Simpson JL, Yang IA, Upham JW, James A, Gibson PG, Reynolds P. Blood cytotoxic/inflammatory mediators in non-eosinophilic asthma. Clin Exp Allergy 2016 Jan; 46(1):60-70. doi: 10.1111/cea.12634. 
  57. Pizzutto SJ, Upham JW, Yerkovich ST, Chang AB. Inhaled non-steroid anti-inflammatories for children and adults with bronchiectasis. Cochrane Database Syst Rev. 2016 Jan 27;(1):CD007525. doi: 10.1002/14651858.CD007525.pub3. Review. PubMed PMID: 26816298. 
  58. Simpson JL, Daly J, Baines KJ, Yang IA, Upham JW, Reynolds PN, Hodge S, James AL, Hugenholtz P, Willner D, Gibson PG. Airway dysbiosis: Haemophilus influenzae and Tropheryma whipplei in poorly-controlled asthma. Eur Respir J. 2016, 47 (3) 792-800; DOI: 10.1183/13993003.00405-2015. 
  59. Upham JW, Sly PD. Editorial: Vitamin D in Asthma: Is the Golden Bullet Losing its Lustre? Am J Respir Crit Care Med. 2016 Mar 15;193(6):598-600. 
  60. Chang AB, Upham JW, Masters IB, Redding GR, Gibson PG, Marchant JM, Grimwood K. Protracted Bacterial Bronchitis: The Last Decade and the Road Ahead. Pediatric Pulmonology 2016 Mar; 51(3):225-42. doi: 10.1002/ppul.23351. 
  61. Simpson JL, Carroll M, Yang IA, Reynolds PN, Hodge S, James AL, Gibson PG, Upham JW. Reduced anti-viral interferon production in poorly-controlled asthma is associated with neutrophilic inflammation and high dose inhaled corticosteroids. Chest 2016; 149(3):704-713. doi:10.1016/j.chest.2015.12.018 
  62. Lynch JP, Werder RB, Simpson J, Loh Z, Zhang V, Haque A, Spann K, Sly PD, Mazzone SB, Upham JW, and Phipps S. Aeroallergen-induced IL-33 predisposes to respiratory virus-induced asthma by dampening anti-viral immunity J Allergy Clin Immunol. 2016 Nov; 138 (5):1326-37. 
  63. Hodge S, Upham JW, Pizzutto S, Petsky HL, Yerkovich S, Baines KJ, Gibson P, Simpson JL, Buntain H, Chen ACH, Hodge G, Chang AB.  Is alveolar macrophage phagocytic dysfunction in children with protracted bacterial bronchitis a forerunner to bronchiectasis? Chest. 2016;149(2):508-515. doi:10.1016/j.chest.2015.10.066 
  64. Revez JA, Matheson MC, Hui J, Baltic S, James A, Upham JW, Dharmage S, Thompson PJ, Martin NG, Hopper JL and Manuel A.R. Ferreira. Identification of STOML2 as a putative novel asthma risk gene associated with IL6R. Allergy 2016 Jul;71(7):1020-30. doi: 10.1111/all.12869. 
  65. Scott HA, Gibson PG, Garg ML, Upham JW, Wood LG. Sex Hormones and Systemic Inflammation are Modulators of the Obese-Asthma Phenotype. Allergy 2016 Jul;71(7):1037-47. doi: 10.1111/all.12891. 
  66. Simpson JL, Yang IA, Upham JW, Reynolds PN, Hodge S, James AL, Jenkins C, Peters MJ, Jia G, Holweg CT, Gibson PG. Periostin levels and eosinophilic inflammation in poorly-controlled asthma. BMC Pulm Med. 2016 Apr 30;16(1):67. PubMed PMID: 27130294. 
  67. Wurzel D, Marchant J, Yerkovich ST, Upham JW, Petsky H, Vaughan-Smith H, Masters IB, Buntain H, Chang AB. Protracted Bacterial Bronchitis in Children: Natural History and Risk Factors for Bronchiectasis. Chest 2016 Nov; 150(5):1101-1108. 
  68. Hew M, Gillman A, ….Upham JW, McDonald VM, Gibson PG. Real-life effectiveness of omalizumab in severe allergic asthma above the recommended dosing range criteria. Clin Exp Allergy 2016 Nov; 46(11):1407-1415. doi: 10.1111/cea.12774. 
  69. Gibson PG, Reddel H, McDonald VM, Marks G, Jenkins C, Gillman A, Upham J, et al. Effectiveness and response predictors of omalizumab in a severe allergic asthma population with a high prevalence of comorbidities: the Australian Xolair Registry. Intern Med J. 2016 Sep;46(9):1054-62. doi: 10.1111/imj.13166. 
  70. Blyth CC, Macartney KK, Hewagama S, Senenayake S, Friedman ND, Simpson G, Upham J, Kotsimbos T, Kelly P, Cheng AC. Influenza epidemiology, vaccine coverage and vaccine effectiveness in children admitted to sentinel Australian hospitals in 2014: the Influenza Complications Alert Network (FluCAN). Euro Surveill. 2016 Jul 28;21(30). doi: 10.2807/1560-7917.ES.2016.21.30.30301. PubMed PMID: 27494798. 
  71. Upham JW, Xi Y. Dendritic cells in human lung disease: recent advances. Chest 2017; 151(3): 668-673. DOI: http://dx.doi.org/10.1016/j.chest.2016.09.030 
  72. Upham JW, Gleeson SA. Combination long-acting bronchodilators for COPD. Medicine Today 2016 April; 17:73-74 
  73. Upham JW, Galt LM. What’s new in asthma treatment? Respiratory Medicine Today 2016; 1(1): 26-29 
  74. Kunarajah K, Pena O and Upham JW. Understanding the immune and inflammatory response to rhinoviruses: recent advances with relevance to asthma. Current Respiratory Medicine Reviews 2016; 12:215-224 doi: 10.2174/1573398X12666160909102919 
  75. Navarro S, Pickering DA, Ferreira IB, Jones L, Ryan S, Troy S, Leech A…Upham JW, Julia V, Giacomin PR, Loukas A. Hookworm recombinant protein promotes regulatory T cell responses that suppress experimental asthma. Science Translational Medicine  26 Oct 2016:Vol. 8, Issue 362, pp. 362ra143 
  76. McDonald VM, Maltby S, Reddel HK, King GG, Wark PA, Smith L,  Upham JW, James AL, Marks GB and Gibson PG. Severe Asthma: Current Management, Targeted Therapies and Future Directions – A Roundtable Report. Respirology 2017 Jan;22(1):53-60. doi: 10.1111/resp.12957. Review. PubMed PMID: 27905186 
  77. Cheng AC, Holmes M, Dwyer DE, Irving LB, Korman TM, Senenayake S, Macartney KK, Blyth CC, Brown S, Waterer G, Hewer R, Friedman ND, Wark PA, Simpson G, Upham J, Bowler SD, Lessing A, Kotsimbos T, Kelly PM. Influenza epidemiology in patients admitted to sentinel Australian hospitals in 2015: the Influenza Complications Alert Network. Commun Dis Intell Q Rep. 2016 Dec 24;40(4):E521-E526. PubMed PMID: 28043227. 
  78. Gupta D, Winckel K, Burrows J, Ross J, Upham JW. Utilisation of nicotine replacement therapy within a hospital pharmacist initiated smoking-cessation intervention - A pragmatic randomised controlled trial. Journal of Smoking Cessation 2017 March; 12 (1): 45-54 
  79. Arikkatt J, Ullah MA, Short KR, Zhang V, Gan WJ, Loh Z, Werder RB, Simpson J, Sly PD, Mazzone SB, Spann KM, Ferreira MA, Upham JW, Sukkar MB, Phipps S. RAGE deficiency predisposes mice to virus-induced paucigranulocytic asthma. Elife. 2017 Jan 18;6. pii: e21199. PubMed PMID: 28099113. 
  80. Fricker M, Heaney LG, Upham JW. Can biomarkers help us hit targets in difficult-to-treat asthma? Respirology 2017 Apr;22(3):430-442. doi:10.1111/resp.13014. PMID: 28248008 
  81. Hukins C, Wong M, Murphy M, Upham JW. "Management of Hypoxaemic Respiratory Failure in a Respiratory High Dependency Unit" Intern Med J. 2017 Jul; 47(7):784-792. doi: 10.1111/imj.13403. PubMed PMID: 28224729 
  82. Gibson PG, Yang IA, Upham JW, Reynolds PN, Hodge S, James AL, Jenkins C, Peters MJ, Marks GB, Baraket M, Powell H, Taylor SL, Leong LE, Rogers GB, Simpson JL. Effect of azithromycin on asthma exacerbations and quality of life in adults with persistent uncontrolled asthma (AMAZES): a randomised, double-blind, placebo-controlled trial. Lancet 2017 Aug 12;390(10095):659-668. doi: 10.1016/S0140-6736(17)31281-3. PMID: 28687413 
  83. Pizzutto SJ, Hare KM, Upham JW. Bronchiectasis in children: Current concepts in immunology and microbiology. Front Pediatr. 2017 May 29; 5:123. doi:10.3389/fped.2017.00123. eCollection 2017. Review. PubMed PMID: 28611970 
  84. Chen AC-H, Xi Y, Carroll M, Petsky HL, Gardiner SJ, Pizzutto SJ, Yerkovich ST, Baines KJ, Gibson PG, Hodge S, Masters IB, Buntain HM, Chang AB, Upham JW. Cytokine responses against two common respiratory pathogens in children are dependent on IL-1β. ERJ Open Research 2017 3: 00025-2017; DOI: 10.1183/23120541.00025-2017. 
  85. Xi Y, Troy NM, Anderson D, Pena OM, Lynch JP, Phipps S, Bosco A, JW Upham. Critical role of plasmacytoid dendritic cells in regulating gene expression and innate immune responses to human rhinovirus 16. Frontiers in Immunology 2017; 8: 1351. DOI=10.3389/fimmu.2017.01351 
  86. Cheng AC, Holmes M, Dwyer DE, Irving L, Korman T, Senenayake S, Macartney K, Blyth C, Brown S, Waterer G, Cooley L, Friedman ND, Wark P, Simpson G, Upham J, Bowler S, Brady S, Kotsimbos T, Kelly P. Influenza epidemiology in patients admitted to sentinel Australian hospitals in 2016: the Influenza Complications Alert Network (FluCAN). Commun Dis Intell Q Rep. 2017 Dec 1;41(4):E337-E347. PubMed PMID: 29864387. 
  87. Taylor SL, Leong L, Choo JM, Wesselingh S, Yang IA, Upham JW, Reynolds PN, Hodge S, James AL, Jenkins C, Peters MJ, Baraket M, Marks GB, Gibson PG, Simpson JL, Rogers GB. Inflammatory phenotypes in severe asthma are associated with distinct airway microbiology. J Allergy Clin Immunol 2018 Jan; 141: 94-103. PubMed PMID: 28479329
  88. Lynch JP, Werder RB, Loh Z, Sikder MA, Curren B, Zhang V, Rogers M, Lane K, Simpson J, Mazzone S, Spann K, Hayball J, Diener K, Everard M, Blyth C, Forstner C, Dennis P, Murtaza N, Morrison M, Cuiv PO, Zhang P, Hill G, Sly PD, Haque A, Upham JW, Phipps S. Plasmacytoid dendritic cells protect from viral bronchiolitis and asthma through semaphorin 4a-mediated T reg expansion. J Exp Med 2018; 215: 537-557. doi: 10.1084/jem.20170298. PubMed PMID: 29273643.
  89. Revez JA, Killian K, O’Byrne PM, Boulet L-P, Upham JW, Gauvreau GM, Ferreira MA. Sputum cytology during late phase responses to inhalation challenge with different allergens. Allergy 2018; 73 (7): 1470-1478. doi.org/10.1111/all.13415 PubMed PMID: 29337345.
  90. Teoh L, Mackay IM, Van Asperen PP, Acworth JP, Hurwitz M, Upham JW, Siew WH, Wang CYT, Sloots TP, Neeman T, Chang AB. Presence of atopy increases the risk of asthma relapse. Arch Dis Child. 2018 Apr;103(4):346-351. doi: 10.1136/archdischild-2017-312982. PubMed PMID: 29021189.
  91. Chen AC-H, Tran H, Xi Y, Yerkovich ST, Baines K, Pizzutto S, Carroll M, Robertson A, Cooper M, Schroder K, Simpson J, Gibson PG, Hodge G, Masters IB, Buntain H, Petsky H, Gardiner S, Chang AB, Hodge S, Upham JW. Multiple inflammasomes may regulate the IL-1-driven inflammation in protracted bacterial bronchitis. ERJ Open Research 2018 Mar 23;4(1). pii: 00130-2017. doi:10.1183/23120541.00130-2017. eCollection 2018 Jan. PubMed PMID: 29594175
  92. Chen AC-H, Pena OM, Nel HJ, Yerkovich ST, Chang AB, Baines KJ, Gibson PG, Petsky HL,  Pizzutto SJ, Hodge S, Masters IB, Buntain HL, Upham JW. Airway cells from protracted bacterial bronchitis and bronchiectasis share similar gene expression profiles. Pediatric Pulmonology 2018 May;53(5):575-582. doi: 10.1002/ppul.23984. PMID: 29575797
  93. Werder RB, Zhang V, Lynch JP, Snape N, Upham JW, Spann K, Phipps S. Chronic IL-33 expression predisposes to viral-induced exacerbations of asthma by increasing type-2 inflammation and dampening antiviral immunity. J Allergy Clin Immunol 2018 May;141(5):1607-1619.e9. doi: 10.1016/j.jaci.2017.07.051. PMID: 28947081
  94. Werder RB, Lynch JP, Simpson JC, Zhang V, Hodge NH, Poh M, Forbes-Blom E, Kulis C, Smythe ML, Upham JW, Spann K, Everard ML, Phipps S. PGD2/DP2 receptor activation promotes severe viral bronchiolitis by suppressing IFN-λ production. Science Translational Medicine 2018 May; Vol. 10, Issue 440, eaao0052. DOI: 10.1126/scitranslmed.aao0052
  95. Hiles S, Harvey E, McDonald V, Peters M, Bardin P, Reynolds P, Upham JW, Baraket M, et al, Working while unwell: Workplace impairment in people with severe asthma. Clin Exp Allergy 2018 Vol. 48 (6):650-662. doi: 10.1111/cea.13153. PMID: 29676834
  96. Upham JW, Chung LP. Optimising treatment for severe asthma. Med J Aust 2018; July 16; 209 (2): S22-S27. || doi: 10.5694/mja18.00175
  97. Upham JW. The Bronchial Epithelial IgE Secretory IgA System in Asthma. Amer J Resp Crit Care Med 2018 Nov 1;198(9):1236. PMID: 30059233
  98. Jurak LM, Xi Y, Landgraf M, Carroll M, Murray L, Upham JW. Interleukin 33 selectively augments rhinovirus-induced type 2 immune responses in asthmatic but not healthy people. Frontiers in Immunology 2018 Aug 16;9:1895. doi:10.3389/fimmu.2018.01895. PMID: 30174671
  99. Chung LP, Hew M, Bardin P, McDonald VM, Upham JW. Managing patients with severe asthma in Australia: current challenges with the existing models of care. Intern Med J 2018 Dec; 48(12):1536-1541. doi: 10.1111/imj.14103. https://doi.org/10.1111/imj.14103. PMID: 30517993
  100. Menzies-Gow A, Canonica GW, Winders T, Correia de Sousa J, Upham JW, Fink-Wagner AH. A Charter to Improve Patient Care in Severe Asthma. Adv Ther 2018; Oct;35(10):1485-1496 https://doi.org/10.1007/s12325-018-0777-y. PMID: 30182174
  101. Fanning M, Upham J. Reducing the burden of severe asthma. Respiratory Medicine Today 2018; 3(2): 10-14.
  102. McDonald VM, S. A. Hiles, K. Godbout, E. S. Harvey, G. B. Marks, M. Hew, M. Peters, P. Bardin, P. N. Reynolds, JW Upham, et al. Treatable traits can be identified in a severe asthma registry and predict future exacerbation. Respirology 2019; Jan; 24:37-47. doi: 10.1111/resp.13389. PMID: 30230137
  103. Murray L, Xi Y, Upham JW. CLEC4C gene expression can be used to quantify circulating plasmacytoid dendritic cells. J Immunol Methods 2019 Jan; 464:126-130 doi: 10.1016/j.jim.2018.11.001. PMID 30395816.
  104. Marsh R, Smith-Vaughan H, Chen A, Marchant J, Yerkovich S, Gibson PG, Pizzutto S, Hodge S, Upham JW, Chang AB. Multiple respiratory microbiota profiles are associated with lower airway inflammation in children with protracted bacterial bronchitis. Chest 2019 2019 Apr;155(4):778-786. doi: 10.1016/j.chest.2019.01.002. Epub 2019 Jan 17. PubMed PMID: 30660785.
  105. Fricker M, Gibson PG, Powell H, Simpson JL, Yang IA, Upham JW et al. A sputum 6 gene signature predicts future exacerbations of poorly controlled asthma. J Allergy Clin Immunol 2019 2019 Jul;144(1):51-60.e11. doi:10.1016/j.jaci.2018.12.1020. Epub 2019 Jan 22. PubMed PMID: 30682452
  106. Chang AB, Fong SM, Yeo TW, Ware RS, McCallum GB, Nathan AM, Ooi MH, de Bruyne J, Byrnes CA, Lee B, Nachiappan N, Saari N, Torzillo PJ, Smith-Vaughan H, Morris PS, Upham JW, Grimwood K. Hospitalised Pneumonia Extended (HOPE) Study to reduce the long-term effects of childhood pneumonia: protocol for a multicentre, double-blind parallel, superiority randomised controlled trial. BMJ Open 2019 Apr 24;9(4):e026411. doi: 10.1136/bmjopen-2018-026411. PubMed PMID: 31023759
  107. Taylor SL, Leong LEX, Mobegi FM, Choo JM, Wesselingh S, Yang IA, Upham JW, Reynolds PN, et al. Long-Term Azithromycin Reduces Haemophilus influenzae and Increases Antibiotic Resistance in Severe Asthma. Am J Respir Crit Care Med. 2019 Aug 1;200(3):309-317. doi: 10.1164/rccm.201809-1739OC. PubMed PMID: 30875247.
  108. Upham JW. Contemporary Concise Review 2018: Asthma and chronic obstructive pulmonary disease. Respirology 2019 Jul;24(7):693-699. doi: 10.1111/resp.13553. Epub 2019 Apr 3. Review. PMID: 30945412
  109. Maltby S, Gibson PG, Reddel HK, Smith L, Wark PAB, King GG, Upham JW, Clark VL, et al. The Severe Asthma Toolkit: An Online Resource for Multidisciplinary Health Professionals. submitted
  110. Narla SP, Upham JW. “Immunity to rhinoviruses”. Book Chapter In: Bartlett N, Wark P, Knight D, (eds). Rhinovirus Infections: Rethinking the Impact on Human Health and Disease. San Diego: Elsevier Inc./Academic Press, 2019: p99-119.
  111. Revez JA, Bain LM, Watson RM, Towers M, Collins T, Killian KJ, O'Byrne PM, Gauvreau GM, Upham JW, Ferreira MA. Effects of interleukin-6 receptor blockade on allergen-induced airway responses in mild asthmatics. Clin Transl Immunology. 2019 Jun 14;8(6):e1044. doi: 10.1002/cti2.1044. eCollection 2019. PubMed PMID: 31223480.
  112. Cheng AC, Holmes M, Dwyer DE, Senanayake S, Cooley L, Irving LB, Simpson G, Korman T, Macartney K, Friedman ND, Wark P, Howell A, Blyth CC, Bowler S, Upham J, Waterer GW, Kotsimbos T, Kelly PM. Influenza epidemiology in patients admitted to sentinel Australian hospitals in 2017: the Influenza Complications Alert Network (FluCAN). Commun Dis Intell (2018). 2019 Sep 16;43. doi:10.33321/cdi.2019.43.39. PubMed PMID: 31522661.
  113. Cesana-Nigro N, Keshvari S, Barclay JL, Sorbello J, Upham JW, Benham H,. Anderson ST, Steiger N, Prins JB, Inder WJ. The effect of glucocorticoids on Thrombospondin-1, Osteocalcin and the Thrombospondin-1:Osteocalcin ratio in humans. Clin Endocrinol (Oxf). 2019 Oct 14. DOI: 10.1111/cen.14108. PMID: 31612515
  114. Kerstjens HAM, Upham JW, Yang IA. Airway pharmacology: treatment options and algorithms to treat patients with chronic obstructive pulmonary disease. J Thorac Dis 2019; 11(suppl 17):S2200-S2209.. doi: 10.21037/jtd.2019.10.57
  115. Chung LP, Upham JW, Bardin PG, Hew M. Rational oral corticosteroid use in adult severe asthma: A narrative review. Respirology 2019 (in press; accepted 22 October 2019). DOI: 10.1111/resp.13730
  116. Cheng AC, Holmes M, Dwyer DE, Senanayake S, Cooley L, Irving LB, Simpson G, Korman T, Macartney K, Friedman ND, Wark P, Howell A, Blyth CC, Crawford N, Buttery J, Bowler S, Upham JW, Waterer GW, Kotsimbos T, Kelly PM. Influenza epidemiology in patients admitted to sentinel Australian hospitals in 2018: the Influenza Complications Alert Network (FluCAN). Commun Dis Intell (2018). 2019 Nov 18;43. doi: 10.33321/cdi.2019.43.48. PubMed PMID: 31738866.
  117. Gibson PG, Yang IA, Upham JW, Reynolds PN, Hodge S, James AL, Jenkins C, Peters MJ, Marks GB, Baraket M, Powell H, Simpson JL. Efficacy of azithromycin in severe asthma from the AMAZES randomised trial. ERJ Open Res. 2019 Dec 23;5(4). pii: 00056-2019. doi: 10.1183/23120541.00056-2019. eCollection 2019 Oct. PubMed PMID: 31886156.
  118. Kailaivasan TH, Timbrell VL, Solley G, Smith W, McLean-Tooke A, van Nunen S, Smith P, Upham JW, Langguth D, Davies JM. Biogeographical variation in specific IgE recognition of temperate and subtropical grass pollen allergens in allergic rhinitis patients. Clinical & Translational Immunology 2019 (in press accepted 29/12/2019). DOI: 10.1002/cti2.1103
  119. Hodge S, Macowan M, Liu H, Hamon R, Chen AC-H., Marchant JM, Pizzutto SJ, Upham JW, Chang AB. Sphingosine signalling dysfunction in airway cells as a potential contributor to progression from protracted bacterial bronchitis to bronchiectasis in children. Pediatric Pulmonology (in press; accepted 24/01/2020)

 

Research fields

Lung disease, immunology, allergy

Connect

ResearcherIDORCID