Dr Johanna Barclay


Senior Research Officer



About me

I completed my PhD from the School of Biomedical Sciences, University of Queensland in 2007 studying cell signaling events involved in breast cancer, under Professor Jon Curlewis.  I then worked on growth hormone and its involvement in metabolic function using preclinical models of obesity and diabetes, based at the Institute for Molecular Biosciences, University of Queensland with Professor Mike Waters.  From there, I moved to the Max Planck Institute for Biophysical Chemistry in Germany where I studied the impact of circadian dysfunction (shift work and jet lag) on metabolic health with Professor Henrik Oster. I was then offered invited back to the University of Queensland (School of Medicine) Metabolic Health group based at the Transitional Research Institute, studying brown adipose tissue in humans, and its role in obesity. I am currently part of the Mater Research Institute Metabolic Medicine team based at the Transitional Research Institute, studying adipose tissue structure and function with view to finding new therapeutic targets to minimise the obesity and its comorbidities.


A. H. Tsang, J. L. Barclay, H. Oster, Interactions between endocrine and circadian systems. J Mol Endocrinology (2013) Aug 30.

C. Benedict, J. L. Barclay, V. Ott, H. Oster, M. Hallschmid, Acute sleep deprivation delays the glucagon-like peptide 1 peak response to breakfast in healthy men. Nutr Diabetes (2013) Jun 24;3:e78.

J. L. Barclay, A. Shostak, A. Leliavski, A. H. Tsang, O. Jöhren, H. Müller-Fielitz, D. Landgraf, N. Naujokat, G. T. van der Horst, H. Oster, High-fat diet-induced hyperinsulinemia and tissue-specific insulin resistance in Cry-deficient mice. Am J Physiol Endocrinol Metab. (2013) May;304(10):E1053-63.

J. L. Barclay*, A. Leliavski*, H. Oster, Circadian Clocks & Eating Disorders. International Journal of Medical and Biological Frontiers, Nova Publishers (2012) in press

J. L. Barclay, A. H. Tsang, & H. Oster, Interaction of central and peripheral clocks in physiological regulation. In: The Neurobiology of Circadian Timing, Progress in Brain Research (2012), Elsevier Publishers. In press

J. L. Barclay, J. Husse, B. Bode, N. Naujokat, J. Meyer-Kovac, S. M. Schmid, H. Lehnert, H. Oster, Circadian desynchrony promotes metabolic disruption in a mouse model of shiftwork, PloS ONE (2012) 7(5):e37150

J. L. Barclay, J. Husse and H. Oster, Adrenal glucocorticoids as a target for jet lag therapies, Expert Review of Endocrinology & Metabolism (2011) 6(5):673-9

J. L. Barclay*, A. Leliavski*, H. Oster, Circadian Clocks & Eating Disorders. In: L. Golovkin and A. Maliszkewicz, ed. Circadian Rhythms: Biology, Cognition and Disorders (2011), Nova Science Publishers. Ch. 1

J. L. Barclay*, C.N. Nelson*, M. Ishikawa, L.A. Murray, L.M. Kerr, T.R. McPhee, E.E. Powell, M.J. Waters, GH-dependent STAT5 signaling plays an important role in hepatic lipid metabolism, Endocrinology (2011) 152(1):181-92 (Endocrinology Outstanding Paper Award 2011)

J. L. Barclay*, L.M. Kerr*, J.E. Rowland, C.N. Nelson, M. Ishikawa, E.M. d’Aniella, M. White, P.G. Noakes, M.J. Waters, In vivo targeting of the growth hormone receptor (GHR) Box1 sequence demonstrates that the GHR does not signal exclusively through JAK2, Molecular Endocrinology (2010) 24: 204-217

S. T. Anderson, N.N. Isa, J.L. Barclay, M.J. Waters, J. D. Curlewis, Maximal expression of suppressors of cytokine signaling in the rat ovary occurs in late pregnancy, Reproduction (2009) 138:537-44

J. L. Barclay, S. T. Anderson, M. J. Waters, J. D. Curlewis, SOCS3 as a tumor suppressor in breast cancer cells, and its regulation by PRL, International Journal of Cancer (2008) Nov 24.

S. W. Rowlinson, Hi. Yoshizato, J. L. Barclay, A. J. Brooks, S. N. Behncken, L. M Kerr, K. Millard, K. Palethorpe, K. Nielsen, J. Clyde-Smith, J. F. Hancock, M. J. Waters, An agonist-induced conformational change in the Growth Hormone (GH) receptor determines choice of signalling pathway, Nature Cell Biology (2008) 10: 740-747

J. L. Barclay, S. T. Anderson, M. J. Waters, J. D. Curlewis, Regulation of SOCS3 by GH in Pro-B cells, Molecular Endocrinology (2007) 21: 2503-2515 (awarded cover)

J. L. Barclay, S. T. Anderson, M. J. Waters, J. D. Curlewis, Characterization of the SOCS3 promoter response to PGE2 in T47D cells, Molecular Endocrinology (2007) 21: 2516-2528

M. J. Waters, J. L. Barclay, Does growth hormone drive breast and other cancers?, Endocrinology (2007) 10: 4533-4535

S. T. Anderson, J. L. Barclay, D.H.L. Kusters, Fanning K, M. J. Waters, J. D. Curlewis,Mechanisms underlying the diminished sensitivity to prolactin negative feedback during lactation: reduced STAT5 signalling and upregulation of Cytokine-Inducible SH2-domain-containing protein (CIS) expression in tuberoinfundibular dopaminergic neurons.  Endocrinology (2006) 147: 1195-202

Curlewis J D, Tam S P, Lau P, Kusters D H L, Barclay J L, Anderson S T, Waters M J, A prostaglandin f(2alpha) analogue induces suppressors of cytokine signalling –3 expression in the corpus luteum of the pregnant rat: a potential new mechanism in luteolysis. Endocrinology (2002) 143:3984-93

J.D. Curlewis, D.H.L. Kusters, J.L. Barclay and S.T. Anderson. Prolactin-Releasing Peptide (PrRP) in the ewe: cDNA cloning, mRNA distribution and effects on prolactin secretion in vitro and in vivo.  J Endocrinology (2002) 174:45-53

N E Saxton, J L Barclay, A D Clouston and J Fawcett.  Cyclosporin A pretreatment in a rat model of warm ischaemia/reperfusion injury. J Hepatology (2002) 36:241-7

* Authors contributed equally to this work

Research fields

Metabolic Medicine