Dr Janet Reid

PhD (QUT), Grad. Dip. Biotech. (QUT), B. Sc. Microbiology (UQ)


Kallikrein-related peptidase 14: Enzymatic charaterization and involvement in novel proteolytic cascades in prostate cancer.

Proteases in prostate cancer


He, Y., Wortmann, A., Burke, L.J., Reid, J.C., Adams, M.N., Abdul-Jabbar, I., Quigley, J.P., Leduc, R., Kirchhofer, D., and Hooper, J.D. (2010). Proteolysis-induced N-terminal ectodomain shedding of the integral membrane glycoprotein CUB domain-containing protein 1 (CDCP1) is accompanied by tyrosine phosphorylation of its C-terminal domain and recruitment of Src and PKCdelta. J Biol Chem 285, 26162-26173. PMID:    20551327


Ramsay, A.J., Reid, J.C., Adams, M.N., Samaratunga, H., Dong, Y., Clements, J.A., and Hooper, J.D. (2008a). Prostatic trypsin-like kallikrein-related peptidases (KLKs) and other prostate-expressed tryptic proteinases as regulators of signalling via proteinase-activated receptors (PARs). Biological chemistry 389, 653-668. PMID:    18627286


Ramsay, A.J., Reid, J.C., Velasco, G., Quigley, J.P., and Hooper, J.D. (2008b). The type II transmembrane serine protease matriptase-2--identification, structural features, enzymology, expression pattern and potential roles. Front Biosci 13, 569-579. PMID:    17981570


Sanchez, W.Y., de Veer, S.J., Swedberg, J.E., Hong, E.J., Reid, J.C., Walsh, T.P., Hooper, J.D., Hammond, G.L., Clements, J.A., and Harris, J.M. (2012). Selective cleavage of human sex hormone-binding globulin by kallikrein-related peptidases and effects on androgen action in LNCaP prostate cancer cells. Endocrinology 153, 3179-3189. PMID:    22547569


Swedberg, J.E., Nigon, L.V., Reid, J.C., de Veer, S.J., Walpole, C.M., Stephens, C.R., Walsh, T.P., Takayama, T.K., Hooper, J.D., Clements, J.A., et al. (2009). Substrate-guided design of a potent and selective kallikrein-related peptidase inhibitor for kallikrein 4. Chemistry & biology 16, 633-643. PMID:    19549601

Research fields

Cancer cell biology