Dr Janet Davies

BSc PhD

Associate Professor

Projects

A multicentre, cross-sectional clinical grass pollen allergy survey.

This project aims to reveal regional differences in allergic sensitivity to different types of grass pollens for evidence-based guidelines on allergen immunotherapy in Australia

Molecular and immunological basis of IgE memory.

This project aims to discover the immunogenetic characteristics of IgE as well as immunological pathways to IgE B cell responses and allergen specific B cell responses in human patients allergic disease.

Allergen component immunodiagnostics and immunotherapy for subtropical grass pollen allergy

Allergen-specific immunotherapy can be protective against hay fever and reduce the risk of asthma, but diagnostics and treatments for subtropical grass pollen allergy are not optimized. Newly patented subtropical allergen components will be used to develop better diagnostic tests and to formulate a more specific allergy vaccine to improve diagnosis and treatment of subtropical grass pollen allergy globally.

Aspects of this research are supported by a stage 2 grant from the National Foundation of Medical Research Innovation.

Current TRI based research project: Blood Test for Subtropical Grass Allergies

The Australian Pollen Allergen Partnership.

The Australian Aerobiology Working Group are aiming to establish the inaugural national pollen monitoring network to assist with management of patients with severe hay fever and allergic asthma. 

This work is funded by the Allergy and Immunology Foundation of Australasia

Allergic responses to pollen allergens, novel diagnostics and theraputics grass pollen allergy

About me

Asoc Prof Davies focuses on applied allergy research to improve diagnosis, treatment and understanding of the immunological mechanism underlying allergic respiratory diseases.  She is the author of 40 peer reviewed papers and her research has been awarded prizes from European Academy of Allergy and Clinical Immunology and Australian Society of Clinical Immunology and Allergy five times.  Dr Davies serves on the World health Organisation IUIS Allergen Nomenclature Committee, the World Allergy Organisation Aeroallergen Committee, the European Academy of Allergy and Clinical Immunology Interest Group on Aerobiology and Air Pollution and the Immunotherapy Working Party of the Australian Society of Clinical Immunology and Allergy. She is an inventor on a patent granted in Australia and three patent applications under examination that underpin development towards more specific immunodiagnosis and treatment for subtropical grass pollen allergy.  The NHMRC, The University of Queensland, The Asthma Foundation of Queensland and The Princess Alexandra Hospital Foundation support her research.  Dr Davies is engaged in collaborative research with the global leaders in allergy diagnosis (ThermoScientific, Sweden) and treatment (Stallergenes, France), the national pathology service provider Sullivan Nicolaides Pathology and Abacus ALS.  

Publications

Australia AU2008/316301 “Novel immunogenic molecules and uses thereof: Immunogenic protein Pas n 1 from Bahia grass pollen.”  Inventors Davies, O'Hehir, Rolland, Accepted for grant, March, 2014. 

PCT/AU2014/000630 “Johnson grass allergenic pollen proteins, encoding nucleic acids and methods of use” Inventor Davies; filed by UQ, June 18, 2014

  1. Campbell B, Gilding E, Timbrell V, Guru P, Loo D, Zennarp D. Mari A, Solley G, Hill M, Godwin I, Davies JM. Total transcriptome, proteome and allergome of pollen of Johnson grass (Sorghum halepense) important for allergic rhinitis in subtropical regions. J Allergy Clin Immunol JACI D-2-13-01665, in press
  2. Kliene-Tebbe J, Davies J “Grass Pollen Allergens” Chapter 3g in the Global Atlas of Allergy. Published by the European Academy of Allergy and Clinical Immunology, 2014, p 22-26.
  3. Haberle S, Bowman D, Newnham R, Johnson F, Beggs P, Buters J, Campbell B, Erbas B, Godwin I, Green B, Huete A, Jaggard A, Medek D, Murray F, Newbigin E, Thibaudon M, Vicendese D, Williamson G, Davies J.  The macroecology of airborne pollen in Australian and New Zealand urban areas. PLoS One 2014, 9; e97925
  4. Davies JM. The contribution of subtropical grass pollen allergens to the global burden of allergic respiratory disease Clin Exp Allergy 2014, 44; 790-801.
  5. Davies JM, Platts-Mills T, Aalberse RC.  The enigma of IgE+ B cell memory in humans  J Allergy Clin Immunol  2013; 131; 972-6.
  6. Etto, T., de Boer, C., Prickett, S, Gardner LM, Voskamp, A., Davies JM,  O’Hehir, RE, Rolland, JM Unique and cross-reactive T cell epitope peptides of the major Bahia grass pollen allergen, Pas n 1. Int Arch Allergy Immunol, 2012;159: 355-366.
  7. Davies JM, Li, HZ, Green, M, Towers, M, Upham, J Subtropical grass pollen allergens are important for allergic respiratory diseases in subtropical regions: implications for allergen-specific immunotherapy  Clin Trans Allergy 2012; 2, 4.
  8. Davies JM, Dang TD, Voskamp A, Drew AC, Biondo M, Phung M, Upham JW, Rolland JM and O'Hehir RE. Functional immunoglobulin E cross-reactivity between Pas n 1 of Bahia grass pollen and other group 1 grass pollen allergens. Clin Exp Allergy. 2011;41; 281-291.
  9. Davies JM, O’Hehir RE.  VH gene usage in IgE responses of seasonal rhinitis patients allergic to grass pollen is oligoclonal and antigen-driven Clin Exp Allergy 2004;34; 429-36.
  10. Davies JM, O’Hehir RE, Suphioglu C. Use of phage display technology to investigate allergen-antibody interactions. J. Allergy Clin Immunol. 2000; 105, 1083-1092.
  11. Myers MA, Davies JM, Tong JC, Whisstock J, Scealy M, Mackay IR, Rowley MJ. (2000) Conformational epitopes on the diabetes autoantigen GAD65 identified by peptide phage-display and molecular modelling. J Immunol. 165: 3830-3838.
  12. Davies JM Molecular mimicry revisited: can epitope mimicry induce autoimmune disease?  Immunol. Cell Biol. 1997;75: 113-126.