Dr James William Wells

Doctor of Philosophy, Bachelor of Science

Senior Research Fellow

    Projects

    About me

    Dr Wells undertook his undergraduate degree in immunology at The University of Edinburgh, and then received his PhD from King’s College London in 2004, working with Dr Joanna Galea-Lauri and Professor Farzin Farzaneh on the generation of novel DC-based vaccines. He then under took two postdoctoral positions: firstly with Dr Alistair Noble at the MRC & Asthma UK Centre in Allergic Mechanisms of Asthma in London (UK) where he studied vaccine-induced modulation of CD8 T-cells, and then with Professor Chris Evans at Harvard University, Boston (USA), where he studied the discovery of modified CD8 T-cell epitopes targeted against genetic translocations. James was then awarded a prestigious 5-year Perpetual Trustees Fellowship to allow him to establish a laboratory in Brisbane, Australia, and was appointed as a Group Leader at the University of Queensland Diamantina Institute in 2011.

    Publications

    Selected Recent Publications

    1. Overgaard, Nana H., Cruz, Jazmina L., Bridge, Jennifer A., Nel, Hendrik J., Frazer, Ian H., La Gruta, Nicole L., Blumenthal, Antje, Steptoe, Raymond J. and Wells, James W. (2017) CD4+CD8β+ double-positive T cells in skin-draining lymph nodes respond to inflammatory signals from the skin. Journal of Leukocyte Biology, 102 3: 837-844. doi:10.1189/jlb.1AB0217-065R

    2. Burke, Michael Thomas, Sambira Nahum, Lauren C., Isbel, Nicole M., Carroll, Robert P., Soyer, Hans Peter, Francis, Ross, Bridge, Jennifer Anne, Hawley, Carmel, Oliver, Kimberly, Staatz, Christine E. and Wells, James William (2017) Sirolimus increases T-cell abundance in the sun exposed skin of kidney transplant recipients. Transplantation Direct,

    3. Bergot, Anne-Sophie, Monnet, Nastasia, Tran, Son Le, Mittal, Deepak, Al-Kouba, Jane, Steptoe, Raymond J., Grimbaldeston, Michele A., Frazer, Ian H. and Wells, James W. (2015) HPV16 E7 expression in skin induces TSLP secretion, type 2 ILC infiltration and atopic dermatitis-like lesions. Immunology and Cell Biology, 93 6: 540-547. doi:10.1038/icb.2014.123

    4. Overgaard, Nana H., Jung, Ji-Won, Steptoe, Raymond J. and Wells, James W. (2015) CD4+/CD8+ double positive T cells: more than just a developmental stage?. Journal of Leukocyte Biology, 97 1: 31-38. doi:10.1189/jlb.1RU0814-382

    5. Bergot, Anne-Sophie, Ford, Neill, Leggatt, Graham R., Wells, James W., Frazer, Ian H. and Grimbaldeston, Michele A. (2014) HPV16-E7 expression in squamous epithelium creates a local immune suppressive environment via CCL2- and CCL5- mediated recruitment of mast cells. PLoS Pathogens, 10 10: 1-11. doi:10.1371/journal.ppat.1004466