Associate Professor Ingrid Winkler

Senior Research Fellow

Projects

About me

Associate Professor Ingrid Winkler is a Senior Research Fellow and head of the Stem Cells and Cancer group at Mater Research, Brisbane, Australia.

Ingrid Winkler’s research focuses on understanding how micro-environments protect and instruct Stem Cells. Her innovative research has already led to several discoveries, such as a novel strategy to protect normal Haematopoietic Stem Cells from chemotherapy or radiation damage.  Research which may lead to a novel strategy to  i. Potentially alleviate the life-threatening side-effects of cancer therapies, and ii. New ways to sensitise cancer cells to standard cancer therapy.

Over the course of her career, Dr Winkler has produced 49 peer-reviewed articles, including a recent landmark study in Nature Medicine 2012, describing a key component of the bone marrow vascular niche (E-selectin) in regulating Haematopoietic Stem Cell self-renewal and chemo-sensitivity and last year her research was recognized to be among ‘Ten of the Best Research Projects’in Australia by the National Health & Medical Research Council.

Publications

Selected Publications

Winkler IG, Barbier V, Nowlan B, et al. Vascular niche E-selectin regulates hematopoietic stem cell dormancy, self renewal and chemoresistance.
 Nature Medicine. 2012;18(11):1651-1657.

Winkler IG, Sims NA, Pettit AR, et al. Bone marrow macrophages maintain hematopoietic stem cell (HSC) niches and their depletion mobilizes HSCs.
 Blood. 2010. 116(23):4815-4828.

Winkler IG, Barbier V, Wadley R, Zannettino AC, Williams S, Levesque JP.
 Positioning of bone marrow hematopoietic and stromal cells relative to blood flow in vivo: serially reconstituting hematopoietic stem cells reside in distinct nonperfused niches.
 Blood. 2010. 116(3):375-385. 

Levesque JP, Winkler IG. Mobilization of hematopoietic stem cells: state of the art.
 Curr Opin Organ Transplant. 2008;13(1):53-58.

Winkler IG, Pettit AR, Raggatt LJ, et al.
 Hematopoietic stem cell mobilizing agents G-CSF, cyclophosphamide or AMD3100 have distinct mechanisms of action on bone marrow HSC niches and bone formation.
 Leukemia. 2012;26(7):1594-1601.

Winkler IG, Bendall LJ, Forristal CE, et al.
 B-lymphopoiesis is stopped by mobilizing doses of G-CSF and is rescued by overexpression of the anti-apoptotic protein Bcl2.
 Haematologica. 2012; 98(3):325-333.

Research fields

Stem Cell and Cancer Group