Dr. Iman Azimi

PhD

Postdoctoral Research Fellow

Projects

About me

Iman Azimi obtained his PhD in 2011 from Lowy Cancer Research Centre, the University of New South Wales in 2011, where he worked on the role of allosteric disulfide bonds on the function of HIV-1 gp120 protein during HIV entry. After completing PhD, Dr Azimi pursued postdoctoral studies in the lab of Prof. Gregory Monteith and Prof. Sarah Roberts-Thomson at the University of Queensland. His research is mainly focused on the role of calcium signalling and oxidative stress in epithelial-mesenchymal transition in breast cancer cells using hypoxia and growth factor models of EMT. Dr Azimi is also undertaking research for the development of monoclonal antibodies and small molecule regulators of a protein involved in breast cancer. Dr Azimi has presented several of his findings at various national and international conferences, and has published his findings in peer reviewed journals.

Publications

  • Azimi I, Beilby H, Davis FM, Marcial DL, Kenny PA, Thompson EW, Roberts-Thomson SJ, Monteith GR (2015). Altered purinergic receptor-Ca2+ signaling associated with hypoxia-induced epithelial-mesenchymal transition in breast cancer cells. Molecular Oncology. Doi: 10.1016/j.molonc.2015.09.006
  • Stewart TA, Azimi I, Thompson EW, Roberts-Thomson SJ, Monteith GR (2015). A role for calcium in the regulation of ATP-binding cassette, sub-family C, member 3 (ABCC3) gene expression in a model of epidermal growth factor-mediated breast cancer epithelial-mesenchymal transition. Biochemical and Biophysical Research Communications. Doi: 10.1016/j.bbrc.2015.01.141
  • Azimi I, Roberts-Thomson SJ, Monteith GR. (2013). Calcium Influx Pathways in Breast Cancer: Opportunities for Pharmacological Intervention. British Journal of Pharmacology. doi: 10.1111/bph.12486
  • Davis FM, Azimi I, Faville RA, Peters AA, Goodhill GJ, Thompson EW, Roberts-Thomson SJ, Monteith GR (2013). Induction of epithelial-mesenchymal transition (EMT) in breast cancer cells is calcium signal dependent. Oncogene, doi: 10.1038/onc.2013.187
  • Ross DG, Smart CE, Azimi I, Roberts-Thomson SJ, Monteith GR (2013). Assessment of ORAI1-mediated basal calcium influx in mammary epithelial cells. BMC Cell Biology. doi: 10.1186/1471-2121-14-57.
  • Azimi I, Matthias LJ, Center RJ, Wong JWH, and Hogg PJ (2010). The disulfide bond that constrains the HIV-1 gp120 V3 domain is cleaved by thioredoxin. Journal of Biological Chemistry. 285 (51): 40072–40080
  • Azimi I, Wong JWH, and Hogg PJ (2010). Control of mature protein function by allosteric disulfide bonds. Antioxidants & Redox Signaling. 14 (1): 113- 126.
  • Matthias L., Azimi I, Tabrett CA and Hogg PJ (2010). Reduced monomeric CD4 is the preferred receptor for HIV. Journal of Biological Chemistry285 (52): 40793-4079

Research fields

Breast cancer, Epithelial-mesenchymal transition (EMT), Free radicals, Calcium signalling