Dr Giorgia Mori

PhD

Postdoctoral Researcher

My Research

Discovery of new antimicrobials against Mycobacterium tuberculosis

Projects

About me

Dr. Giorgia Mori received her Master degree at the University of Pavia (UNIPV, Italy) working in the context of the “New Medicines for Tuberculosis” (NM4TB) consortium. Her contribution to the discovery of anti-infective agents against TB continued within the “More Medicines for Tuberculosis” (MM4TB) project, during her PhD in “Biomolecular Sciences and Biotechnology” (Institute for Advanced Studies (IUSS), Pavia, Italy). After her PhD, she successfully applied for a UNIPV sponsored fellowship for studying gut microbiota in patients with sporadic and hereditary colorectal cancer (CRC). She then worked for the European Institute of Oncology (IEO, Milan, Italy) as a Bioinformatician and she is now back on the TB topic with a Postdoctoral position in the A/Prof. Blumenthal’s lab at UQDI.

Publications

  • Mori G*, Orena BS, Cultrera I, Barbieri G, Albertini AM, Ranzani GN, Carnevali I, Tibiletti MG, Pasca MR. Gut microbiota analysis in postoperative Lynch syndrome patients. Frontiers in Microbiology. 2019. In press. (*corresponding author).
  • Mori G, Orena BS, Franch C, Mitchenall LA, Godbole AA, Rodrigues L, Aguilar-Pérez C, Zemanová J, Huszár S, Forbak M, Lane TR, Sabbah M, Deboosere N, Frita R, Vandeputte A, Hoffmann E, Russo R, Connell N, Veilleux C, Kumar R, Kumar P, Freundlich JS, Brodin P, Aínsa JA, Nagaraja V, Maxwell A, Mikušová K, Pasca MR, Ekins S. The EU approved antimalarial pyronaridine shows antitubercular activity and synergy with rifampicin, targeting RNA polymerase. Tuberculosis. 2018. 112:98-109.
  • Mori G*, Rampelli S, Orena BS, Rengucci C, De Maio G, Barbieri G, Passardi A, Casadei Gardini A, Frassineti GL, Gaiarsa S, Albertini AM, Ranzani GN, Calistri D, Pasca MR. Shifts of Faecal Microbiota During Sporadic Colorectal Carcinogenesis. Sci Rep. 2018. 8:10329. (*co-corresponding author).
  • Moulkrere BR, Orena BS, Mori G, Saffon-Merceron N, Rodriguez F, Lherbet C, Belkheiri N, Amari M, Hoffmann P, Fodili M. Evaluation of heteroatom-rich derivatives as antitubercular agents with InhA inhibition properties. Medicinal Chemistry Research. 2018. 27:308-320.
  • Chiarelli LR, Mori G, Orena BS, Esposito M, Lane T, de Jesus Lopes Ribeiro AL, Degiacomi G, Zemanová J, Szádocka S, Huszár S, Palčeková Z, Manfredi M, Gosetti F, Lelièvre J, Ballell L, Kazakova E, Makarov V, Marengo E, Mikusova K, Cole ST, Riccardi G, Ekins S, Pasca MR. A multitarget approach to drug discovery inhibiting Mycobacterium tuberculosis PyrG and PanK. Sci Rep. 2018. 8:3187.
  • Chiarelli LR, Mori M, Barlocco D, Beretta G, Gelain A, Pini E, Porcino M, Mori G, Stelitano G, Costantino L, Lapillo M, Bonanni D, Poli G, Tuccinardi T, Villa S, Meneghetti F. Discovery and development of novel salicylate synthase (MbtI) furanic inhibitors as antitubercular agents. Eur J Med Chem. 2018. 155:754-763.
  • Oliveira PFM, Guidetti B, Chamayou A, André-Barrès C, Madacki J, Korduláková J, Mori G, Orena BS, Chiarelli LR, Pasca MR, Lherbet C, Carayon C, Massou S, Baron M, Baltas M. Mechanochemical Synthesis and Biological Evaluation of Novel Isoniazid Derivatives with Potent Antitubercular Activity. Molecules. 2017. 22.
  • Esposito M, Szadocka S, Degiacomi G, Orena BS, Mori G, Piano V, Boldrin F, Zemanová J, Huszár S, Barros D, Ekins S, Lelièvre J, Manganelli R, Mattevi A, Pasca MR, Riccardi G, Ballell L, Mikušová K, Chiarelli LR. A Phenotypic Based Target Screening Approach Delivers New Antitubercular CTP Synthetase Inhibitors. ACS Infect Dis. 2017.
  • Mori G, Chiarelli LR, Riccardi G, Pasca MR. New prodrugs against tuberculosis. Drug Discov Today. 2017. 22:519-525.
  • Veau D, Krykun S, Mori G, Orena BS, Pasca MR, Frongia C, Lobjois V, Chassaing S, Lherbet C, Baltas M. Triazolophthalazines: Easily Accessible Compounds with Potent Antitubercular Activity. ChemMedChem. 2016. 11:1078-1089.
  • Tiwari R, Miller PA, Chiarelli LR, Mori G, Šarkan M, Centárová I, Cho S, Mikušová K, Franzblau SG, Oliver AG, Miller MJ. Design, Syntheses, and Anti-TB Activity of 1,3- Benzothiazinone Azide and Click Chemistry Products Inspired by BTZ043. ACS Medicinal Chemistry Letters. 2016. 7:266-270.
  • Chollet A, Stigliani JL, Pasca MR, Mori G, Lherbet C, Constant P, Quémard A, Bernadou J, Pratviel G, Bernardes-Génisson V. Evaluation of the inhibitory activity of (aza)isoindolinone- type compounds: toward in vitro InhA action, Mycobacterium tuberculosis growth and mycolic acid biosynthesis. Chem Biol Drug Des. 2016. 88:740-755.
  • Matviiuk T, Madacki J, Mori G, Orena BS, Menendez C, Kysil A, André-Barrès C, Rodriguez F, Korduláková J, Mallet-Ladeira S, Voitenko Z, Pasca MR, Lherbet C, Baltas M. Pyrrolidinone and pyrrolidine derivatives: Evaluation as inhibitors of InhA and Mycobacterium tuberculosis. Eur J Med Chem. 2016. 123:462-75.
  • Chiarelli LR, Mori G, Esposito M, Orena BS, Pasca MR. New and Old Hot Drug Targets in Tuberculosis. Curr Med Chem. 2016. 23:3813-3846.
  • Neres J, Hartkoorn R, Chiarelli L, Gadupudi R, Pasca MR, Mori G, Farina D, Savina S, Makarov V, Kolly G, Molteni E, Binda C, Dhar N, Ferrari S, Brodin P, Delorme V, Landry V, Ribeiro AL, Venturelli A, Saxena P, Pojer F, Carta A, Luciani R, Porta A, Zanoni G, de Rossi E, Costi MP, Riccardi G, Cole ST. 2-Carboxyquinoxalines kill Mycobacterium tuberculosis through non- covalent inhibition of DprE1. ACS Chem Biol. 2015. 10:705-14.
  • Mori G, Chiarelli LR, Esposito M, Makarov V, Bellinzoni M, Hartkoorn RC, Degiacomi G, Boldrin F, Ekins S, de Jesus Lopes Ribeiro AL, Marino LB, Centárová I, Svetlíková Z, Blaško J, Kazakova E, Lepioshkin A, Barilone N, Zanoni G, Porta A, Fondi M, Fani R, Baulard AR, Mikušová K, Alzari PM, Manganelli R, de Carvalho LP, Riccardi G, Cole ST, Pasca MR. Thiophenecarboxamide Derivatives Activated by EthA Kill Mycobacterium tuberculosis by Inhibiting the CTP Synthetase PyrG. Chem Biol. 2015. 22:917-27.
  • Chollet A, Mori G, Menendez C, Rodriguez F, Fabing I, Pasca MR, Madacki J, Korduláková J, Constant P, Quémard A, Bernardes-Génisson V, Lherbet C, Baltas M. Design, synthesis and evaluation of new GEQ derivatives as inhibitors of InhA enzyme and Mycobacterium tuberculosis growth. Eur J Med Chem. 2015. 101:218-235.
  • Menendez C, Mori G, Maillot M, Fabing I, Carayon C, Orena BS, Pasca MR, Lherbet C, Baltas M. Synthesis and evaluation of 2-triazolethanol and a,b-diketotriazoles as antitubercular agents. French-Ukrainian Journal of Chemistry. 2015. 3: 82-96.
  • Perdigão G, Deraeve C, Mori G, Pasca MR, Pratviel G, Bernardes-Génisson V. Pyridine-3,4- dicarboximide as a common starting material for the total synthesis of the natural product eupolauramine and its isomer iso-eupolauramine endowed with anti-tubercular activities. Tetrahedron. 2015. 71:1555–1559.
  • Matviiuk T, Mori G, Lherbet C, Rodriguez F, Pasca MR, Gorichko M, Guidetti B, Voitenko Z, Baltas M. Synthesis of 3-heteryl substituted pyrrolidine-2,5-diones via catalytic Michael reaction and evaluation of their inhibitory activity against InhA and Mycobacterium tuberculosis. Eur J Med Chem. 2014. 71: 46-52.
  • Albesa-Jove D, Chiarelli LR, Makarov V, Pasca MR, Urresti S, Mori G, Salina E, Vocat A, Comino N, Mohorko E, Ryabova S, Pfeiffer B, Lopes Ribeiro AL, Rodrigo-Unzueta A, Tersa M, Zanoni G, Buroni S, Altmann KH, Hartkoorn RC, Glockshuber R, Cole ST, Riccardi G, Guerin ME. Rv2466c mediates the activation of TP053 to kill replicating and non-replicating Mycobacterium tuberculosis. ACS Chem Biol. 2014. 9:1567-75.
  • Incandela ML, Perrin E, Fondi M, de Jesus Lopes Ribeiro AL, Mori G, Moiana A, Gramegna M, Fani R, Riccardi G, Pasca MR. DprE1, a New Taxonomic Marker in Mycobacteria. FEMS Microbiology Letters. 2013. 348: 66-73.
  • de Jesus Lopes Ribeiro AL, Degiacomi G, Ewann F, Buroni S, Incandela ML, R Chiarelli L, Mori G, Kim J, Contreras Dominiguez M, Park YS, Han SJ, Brodin P, Valenti G, Rizzi M, Riccardi G, Pasca MR. Analogous mechanisms of resistance to benzothiazinones and dinitrobenzamides in Mycobacterium smegmatis. PLoS One. 2011. 6: e26675.

Research fields

Antimicrobial resistance, Bioinformatics

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