Dr Francisco Sanchez-Luque

PhD Molecular Biology, Degree in Biology

Research Fellow

Projects

About me

Feb 2014 – present

Research Officer

Mater Medical Research Institute / University of Queensland,

Woolloongabba, Australia

Jan 2013 – Jan 2014

Postdoctoral Researcher

Spanish National Research Council, Department of Molecular Biology

Granada, Andalusia, Spain

Study of the Translation mechanism and Transposition ability of L1Tc retrotransposon Trypanosoma cruzi.Study of the expression level and copy number variation of L1Tc in different T. cruzi strains. Mapping L1Tc insertional polymorphisms.

May 2010 – Dec 2012

Junior Researcher

Spanish National Research Council, Department of Molecular Biology

Granada, Andalusia, Spain

Characterization of functional RNA motifs associated to L1Tc and related retrotransposons in Trypanosomatids. The major studied motifs were an Hepatitis Deltha Virus (HDV)-like ribozyme and a tRNA-like structure at retrotransposons 5'-end RNA.

Oct 2008 – Mar 2009

University of Granada

Certificado de Aptitud Pedagógica, Spanish equivalent to UK Postgraduate Certificate in Education or US Teaching Certificate,

Granada, Spain

Aug 2007 – Oct 2007

Exchange student

Academisch Medisch Centrum Universiteit van Amsterdam, Infection and immunity

Amsterdam, Netherlands

Short stay during PhD studentship for training in HIV handling, specially in inhibition assays.

Jan 2005 – Mar 2009

PhD Student

Spanish National Research Council, Department of Molecular Biology

Granada, Andalusia, Spain

Designing of RNA inhibitors against Human Immunodeficiency Virus type-1 (VIH-1) based on functional RNAs like trans-cleaving engineered ribozymes, RNA decoys, RNA aptamers and antisense RNAs targeting its RNA 5'-untranslated region.

Jan 2005 – Jan 2013

University of Granada

Doctor of Philosophy (PhD), Molecular Biology

Granada, Spain

Apr 2004 – Dec 2004

Laboratory Technician

Spanish National Research Council, Department of Molecular Biology

Granada, Andalusia, Spain

Molecular and cellular biology assistant on research about new RNA molecules targeting HIV-1 RNA.

Jan 2004

Award: Extraordinary Prize for Degree in Biology

Sep 1998 – Jul 2003

University of Cordoba (Spain)

Degree in Biology. Teaching Assistant in Dept. Physiology, Immunology and Cellular Biology; and Dept. Microbiology.

Cordoba, Spain

Publications

Kyle R. Upton, Daniel J. Gerhardt, J. Samuel Jesuadian, Sandra R. Richardson, Francisco J. Sanchez-Luque, Gabriela O. Bodea, Adam D. Ewing, Carmen Salvador-Palomeque, Marjo S. van der Knaap, Paul M. Brenan, Adeline Vanderver, Geoffrey J. Faulkner. Ubiquitous L1 mosaicism in hippocampal neurons. Cell 2015; 161(2):228-39.

Jose A. Reyes-Darias, Francisco J. Sanchez-Luque, Juan C. Morales, Sonia Perez-Rentero, Ramon Eritja, Alfredo Berzal-Herranz. Glucose conjugation of anti-HIV-1 oligonucleotides containing unmethylated CpG motifs reduces their immunostimulatory activity. ChemBioChem 2015; 16(4):584-91.

Francisco J. Sanchez-Luque, Michael Stich, Susanna Manrubia, Carlos Briones, Alfredo Berzal-Herranz. Efficient HIV-1 inhibition by a 16 nt-long RNA aptamer designed by combining in vitro selection and in silico optimisation strategies. Scientific Reports 2014; 4:6242.

Francisco J. Sanchez-Luque, Manuel C. Lopez, Patricia E. Carreira, Carlos Alonso, M. Carmen Thomas. The wide expansion of hepatitis delta virus-like ribozymes throughout trypanosomatid genomes is linked to the spreading of L1TC/ingi clade mobile elements. BMC Genomics 2013; 15(1):340. Research Article.

José A Reyes-Darias, Francisco J Sánchez-Luque, Alfredo Berzal-Herranz: HIV RNA dimerisation interference by antisense oligonucleotides targeted to the 5' UTR structural elements. Virus Research 07/2012; 169(1):63-71. Research Article.

Francisco Sánchez-Luque, Manuel C López, Francisco Macias, Carlos Alonso, M Carmen Thomas: Pr77 and L1TcRz: A dual system within the 5'-end of L1Tc retrotransposon, internal promoter and HDV-like ribozyme. Mobile genetic elements. 01/2012; 2(1):1-7. Extraview.

Francisco J Sánchez-Luque, Manuel C López, Francisco Macias, Carlos Alonso, M Carmen Thomas: Identification of an hepatitis delta virus-like ribozyme at the mRNA 5'-end of the L1Tc retrotransposon from Trypanosoma cruzi. Nucleic Acids Research 06/2011; 39(18):8065-77. Research Article.

Francisco J Sánchez-Luque, José A Reyes-Darias, Elena Puerta-Fernández, Alfredo Berzal-Herranz: Inhibition of HIV-1 replication and dimerization interference by dual inhibitory RNAs. Molecules 07/2010; 15(7):4757-72. Research Article.

Soledad Marton, José A Reyes-Darias, Francisco J Sánchez-Luque, Cristina Romero-López, Alfredo Berzal-Herranz: In vitro and ex vivo selection procedures for identifying potentially therapeutic DNA and RNA molecules. Molecules 07/2010; 15(7):4610-38. Review.

José A Reyes-Darias, Francisco J Sánchez-Luque, Alfredo Berzal-Herranz: Inhibition of HIV-1 replication by RNA-based strategies. Current HIV research 12/2008; 6(6):500-14. Review.

Rubén A Bartolomé, Natalia Wright, Isabel Molina-Ortiz, Francisco J Sánchez-Luque, Joaquin Teixidó: Activated G(alpha)13 impairs cell invasiveness through p190RhoGAP-mediated inhibition of RhoA activity. Cancer Research 11/2008; 68(20):8221-30. Research Article.

C Romero-López, F J Sánchez-Luque, A Berzal-Herranz: Targets and tools: recent advances in the development of anti-HCV nucleic acids. Infectious Disorders - Drug Targets(Formerly Current Drug Targets - Infectious Disorders) 07/2006; 6(2):121-45. Review.

Alicia Barroso-DelJesus, Elena Puerta-Fernández, Natalia Tapia, Cristina Romero-López, Francisco José Sánchez-Luque, Miguel Angel Martínez, Alfredo Berzal-Herranz: Inhibition of HIV-1 replication by an improved hairpin ribozyme that includes an RNA decoy. RNA biology 05/2005; 2(2):75-9. Research Article.