Dr Danielle Borg

BAppSci (Hons) PhD

Project Coordinator

Research Themes

Pregnancy and Development

Projects

The gut microbiome in pregnancy and early life: what are its determinants and how is it related to outcomes?

About me

Danielle is the program coordinator for the QLD family cohort study at the Mater Research Institute. Her passion in medical research was sparked during her PhD in type 1 diabetes with a leading immunologist in Germany, at the Centre for Regenerative Therapies, Technische Universität Dresden. Her interest in chronic disease continued in Australia into type 1 diabetes therapeutics, focusing on advanced glycation end product biochemical pathways, and type 2 diabetes therapeutics, focusing on interleukin-22, under the mentorship of highly-cited biochemists and immunologists. She has 10 years of research experience in the fields of Diabetes, Cell Transplantation, Cell Imaging and Biochemistry. Throughout her research career, she published peer-reviewed publications, obtained funding for projects, and enjoyed the collaborative nature of medical research.

Danielle’s interest lies in improving health outcomes to the community via the translation of innovative findings from basic and clinical research. This overarching interest prompted her move to clinical research and study coordination in projects focusing on developmental origins of disease, maternal health and pregnancy and child outcomes, after the birth of her first child. She thrives on scientific communication and is an avid believer in giving back to the wider scientific community sitting on numerous committees, grant reviewing and has volunteered for several organisations. Danielle is excited to be a part of a longitudinal birth cohort study which will allow QLD, her home state, to collaborate with other national birth cohort studies and provide relevant information provided by QLD families to help understand how to improve health and child outcomes for years to come.

Publications

  1. Sherman S. Leung, Danielle J. Borg, Domenica A. McCarthy, Tamar E. Boursalian, Justen Cracraft, Aowen Zhuang, Amelia K. Fotheringham, Nicole Flemming, Thomas Watkins, John J. Miles, Per-Henrik Groop, Jean L. Scheijen, Casper G. Schalkwijk, Raymond J. Steptoe, Kristen J. Radford, Mikael Knip, Josephine M. Forbes, Expansion of Functional Regulatory T Cells Using Soluble RAGE Prevents Type 1 Diabetes, Diabetes 2022; db220177. doi.org/10.2337/db22-0177
  2. Vicki L. Clifton; Sailesh Kumar; Danielle Borg; Kym M. Rae; Roslyn N. Boyd; Koa Whittingham; Karen M. Moritz; Hannah E. Carter; Steven M. McPhail; Brenda Gannon, Robert Ware, Barnaby J. W. Dixson, Samudragupta Bora and Cameron Hurst. Associations between COVID-19 lockdown and post-lockdown on the mental health of pregnant women, postpartum women and their partners from the Queensland family cohort prospective study, BMC Pregnancy and Childbirth.  doi.org/10.1186/s12884-022-04795-9.
  3. Shelley A. Wilkinson, Danielle A. J. M. Schoenaker, Susan de Jersey, Clare E. Collins Linda Gallo, Megan Rollo, Danielle Borg, Marloes Dekker Nitert, Helen Truby, Helen L. Barrett, Sailesh Kumar, Vicki Clifton, Exploring the diets of mothers and their partners during pregnancy: Findings from the Queensland Family Cohort pilot study, Nutrition and Dietetics, 2022, 1-14. doi:10.1111/1747-0080.12733.
  4. Linda A. Gallo, Tania F. Gallo, Danielle J. Borg, Karen M. Moritz, Vicki L. Clifton*, Sailesh Kumar*. A decline in planned, but not spontaneous, preterm birth rates in a large Australian tertiary maternity centre during COVID-19 mitigation measures. The Australian and New Zealand Journal of Obstetrics and Gynaecology, 2021, https://doi.org/10.1111/ajo.13406
  5. Borg DJ, Faridi P, Giam KL, Reeves P, Fotheringham AK, McCarthy DA, Leung S, Ward MS, Harcourt BE, Ayala R, Scheijen JL, Briskey D, Dudek NL, Schalkwijk CG, Steptoe R, Purcell AW, Forbes JM. Short Duration Alagebrium Chloride Therapy Prediabetes Does Not Inhibit Progression to Autoimmune Diabetes in an Experimental Model. Metabolites. 2021 Jun 28;11(7):426. doi: 10.3390/metabo11070426.
  6. Danielle J. Borg*, Kym M. Rae*, Corrine E. Fiveash, Johanna M. Schagen, Janelle James-McAlpine, Frances Friedlander, Claire Thurston, Maria Oliveri, Theresa Harmey, Erika Cavanagh, Christopher Edwards, Davide Fontanarosa, Anthony V. Perkins, Greg du Zubicaray, Karen Moritz, Sailesh Kumar, Vicki Clifton on behalf of the Queensland Family Cohort Research Collaborative, The Queensland Family Cohort: Study Protocol, BMJ Open, 2021, 11(6): e044463, doi: 10.1136/bmjopen-2020-044463.
  7. Borg, D.J., Wang, R., Murray, L., Tong, H., Steptoe, R., McGuckin, M., Hasnain, S., The effect of inteleukin-22 on autoimmune diabetes in the NOD mouse, Diabetologia, 2017, 60: 2256.   doi: 10.1007/s00125-017-4392-2
  8. Leung, S., Forbes, J.M.*, and Borg, D.J.*, Receptor for Advanced Glycation End Products (RAGE) in Type 1 Diabetes Pathogenesis, Current Diabetes Reports, 2016,16(10): 100.  doi: 10.1007/s11892-016-0782-y
  9. Danielle J. Borg*, Petra B. Welzel*, Milauscha Grimmer, Jens Friedrichs, Marc Weigelt, Carmen Wilhelm, Marina Prewitz, Aline Stißel, Angela Hommel, Thomas Kurth, Uwe Freudenberg, Ezio Bonifacio, Carsten Werner, Macroporous biohybrid cryogels for co-housing pancreatic islets with mesenchymal stromal cells, Acta Biomateralia, 2016, 15;44: 178-87.  doi: 10.1016/j.actbio.2016.08.007
  10. Salonen, K.M, Ryhaenen, S.J., Forbes, J.M., Borg, D.J., Haekoenen, T., Ilonen, J., Simell, O., Veijola, R., Groop, P-H., Knip, M., Decrease in Circulating Concentrations of Soluble Receptors for Advanced Glycation End Products at the Time of Seroconversion to Autoantibody Positivity in Prediabetic Children. Diabetes Care, 2015; 38(4):665-70.  https://doi.org/10.2337/dc14-1186
  11. Hasnain, S.Z., Borg, D.J., Harcourt, B., Tong, H., NG, C. P., Das, I., Wang, R., Chen, A.C-H., Forbes, J.M., Whitehead, J.P., Prins, J.B. and McGuckin, M.A., IL-22 is an endogenous suppressor of β-cell oxidative and endoplasmic reticulum stress that restores glycemic control in diabetes. Nature Medicine, 2014; 20: 1417-26.  https://doi.org/10.1038/nm.3705
  12. Borg, D.J., Weigelt, M, Wilhelm, C., Gerlach, M., Bickle, M., Speier, S., Bonifacio, E. and Hommel, A, Mesenchymal stromal cells improve transplanted islet survival and islet function in a syngeneic mouse model. Diabetologia, 2014; 57(3): 522-31.  doi: 10.1007/s00125-013-3109-4

Supervision

Sophie Leech (PhD Student)

Research fields

Developmental Origins of Disease, Longitudinal pregnancy and birth cohort outcomes, Immunology and autoimmune diseases, Diabetes Development and Progression, Pancreatic islet dysfunction

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