Burhan Khan

M.Sc. Microbiology & Immunology (Tulane University) | B.A. Biology (Northwestern University)

Visiting Scholar

Projects

Publications

Selected Publications

He L, Le KY, Khan BA, Nguyen TH, Hunt RL, Bae JS, Kabat J, Zheng Y, Cheung GY, Li M, Otto M. Resistance to leukocytes ties benefits of quorum-sensing dysfunctionality to biofilm infection. Nat Microbiol. [in press]

Mukherjee P, Winkler CW, Taylor KG, Woods TA, Khan BA, Nair V, Peterson KE. SARM1, not MyD88, mediates TLR7/TLR9-induced apoptosis in neurons. J Immunol. 195(10):4913-21 (2015).

Khan BA, Yeh AJ, Cheung GY, Otto M. Investigational therapies targeting quorum-sensing for the treatment of Staphylococcus aureus infections. Expert Opin Investig Drugs. 24(5):689-704 (2015).

Cheung GY, Wang R, Khan BA, Sturdevant DE, Otto M. Role of the accessory gene regulator agr in community-associated methicillin-resistant Staphylococcus aureus pathogenesis. Infect Immun. 79(5):1927-35 (2011).

Wang R*, Khan BA*, Cheung GY, Bach TH, Jameson-Lee M, Kong KF, Queck SY*, Otto M. Staphylococcus epidermidis surfactant peptides promote biofilm maturation and dissemination of biofilm-associated infection in mice. J Clin Invest. 121(1):238-48 (2011). *indicates equal contribution to work

Queck SY, Khan BA, Wang R, Bach TH, Kretschmer D, Chen L, Kreiswirth BN, Peschel A, DeLeo FR, Otto M. Mobile genetic element-encoded cytolysin connects virulence to methicillin resistance in MRSA. PLoS Pathog. 5(7):e1000533 (2009).

Villaruz AE, Bubeck-Wardenburg J, Khan BA, Whitney AR, Sturdevant DE, Gardner DJ, DeLeo FR, Otto M. A point mutation in the agr locus rather than expression of the Panton-Valentine leukocidin caused previously reported phenotypes in Staphylococcus aureus pneumonia and gene regulation. J Infect Disease. 200(5):724-34 (2009).

Queck SY, Jameson-Lee M, Villaruz AE, Bach TH, Khan BA, Sturdevant DE, Ricklefs SM, Li M, Otto M. RNAIII-independent target gene control by the agr quorum-sensing system: Insight into the evolution of virulence regulation in Staphylococcus aureus. Mol Cell. 32(1):150-8 (2008).