Mr Benedict Lum

BBiomedSc (Hons)

PhD Candidate

Research Themes

Cancer and Blood Diseases
Immunology and Bone

My Research

Immuno-oncological research

Projects

Improving the efficacy of monoclonal antibodies via dynamin inhibition

Monoclonal antibodies are used in cancer as a drugs that binds to overexpressed receptors on cancer cells. Receptor targets can be trafficked in and out of the cell which affects the ability of monoclonal antibody drugs to perform its function when target receptors are hidden intracellularly in cancer cells. Furthurmore, monoclonal antibodies when bound to cancer cells on the surface mediates immune reconition and immune mediated cancer cell killing by natural killer cells a process known as antibody dependent cell cytotoxicity (ADCC). For this to effectively occur, bound monoclonal antibodies must remain clustered on the cancer cell surface membreane. Our research work explores ways we can stop the trafficking of receptor targets into cancer cells, potentiating the efficacy of monoclonal antibody treatment.

About me

PhD candidate at the University of Qld studying combination cancer immunology treatments

Publications

Hui Yi Chew, Priscila O. De Lima, Jazmina L. Gonzalez Cruz, Blerida Banushi, Godwins Echejoh, Lingbo Hu, Shannon R. Joseph, Benedict Lum, James Rae, Jake S. O’Donnell, Lilia Merida de Long, Satomi Okano, Brigid King, Rachael Barry, Davide Moi, Roberta Mazzieri, Ranjeny Thomas, Fernando Souza-Fonseca-Guimaraes, Matthew Foote, Adam McCluskey, Phillip J. Robinson, Ian H. Frazer, Nicholas A. Saunders, Robert G. Parton, Riccardo Dolcetti, Katharine Cuff, Jennifer H. Martin, Benedict Panizza, Euan Walpole, James W. Wells, Fiona Simpson, Endocytosis Inhibition in Humans to Improve Responses to ADCC-Mediating Antibodies, Cell, Volume 180, Issue 5, 2020, Pages 895-914.e27, ISSN 0092-8674, https://doi.org/10.1016/j.cell.2020.02.019.

Connect

ORCID