Dr Anthony Raphael

BBiot (Hon 1), PhD

University of Queensland Postdoctoral Research Fellow

About me

APPOINTMENTS

Jan 2015 – 2018           NHMRC CJ Martin Fellow

May 2014 – Present      Postdoctoral Research Fellow, Wellman Centre for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Massachusetts, Boston, USA.

Jan 2014                       The University of Queensland Postdoctoral Research Fellow, Dermatology Research Centre, School of Medicine, University of Queensland, Brisbane, Australia.

Aug 2012 – Present       Postdoctoral Research Fellow, Dermatology Research Centre, School of Medicine, University of Queensland, Brisbane, Australia.

Jan 2012                        Research Assistant, Dermatology Research Centre, School of Medicine, University of Queensland, Brisbane, Australia.

EDUCATION

2008 – 2012                   PhD in Biomedical Engineering, The University of Queensland, Brisbane, Australia. Thesis: Dissolving Nanopatches for Targeted Vaccine Delivery to the Skin. Principal Advisor: Prof Mark Kendall

Fall 2005                        International student exchange (Biotechnology), The University of Wisconsin-Madison, USA.

2004 – 2007                   Bachelor Biotechnology (Honours 1st) in the field of Nanotechnology, The University of Queensland, Brisbane, Australia.

Projects

Publications

  1. Raphael AP, et al. Formulation design for topical drug and nanoparticle treatment of skin disease. Therapeutic Delivery. Accepted 24/10/14.
  2. Zhang L, Raphael AP, et al. Nanodispersed UV blockers in skin friendly silica vesicles with superior UV-attenuating efficiency. J Mater Chem B. Accepted 02/09/14.
  3. Raphael AP, et al. Enhanced delivery of nano- and submicron particles using elongated microparticles. Current Drug Delivery. Accepted 26/08/14.
  4. Mohammed YH, Yamada M, Lin LL, Grice JE, Roberts MS, Raphael AP, et al. Microneedle enhanced delivery of cosmeceutically relevant peptides in human skin. PLoS ONE. 2014;9(7):e101956.
  5. Raphael AP, et al. High aspect ratio elongated microparticles for enhanced topical drug delivery in human volunteers. Adv Healthcare Mater. 2014;3(6):860-6.
  6. Yan L, Raphael AP, et al. Nanocomposite strengthened dissolving microneedles for improved transdermal delivery to human skin. Adv. Healthcare Mater. 2014;3(4):555-64.
  7. Raphael AP, et al. Elongate microparticles for enhanced drug delivery to ex vivo and in vivo pig skin. J Control Release. 2013;172(1):96-104.
  8. Lin L, Prow TW, Raphael AP, et al. Microbiopsy engineered for minimally invasive and suture-free sub-millimeter skin sampling. F1000Research. 2013;2(120).
  9. Raphael AP, et al. Computational characterization of reflectance confocal microscopy features potential for automated photoageing assessment. Exp Dermatol. 2013;22(7):458-463.
  10. Raphael AP, et al. Zinc oxide nanoparticle removal from wounded human skin. Nanomedicine. 2013;8(11):1751-61.
  11. Raphael APδ, Meliga SCδ, et al. Depth-resolved characterization of diffusion properties within and across minimally-perturbed skin layers. J Control Release. 2013;166(2):87-94. δEqual contributors.
  12. Liu DC, Raphael AP, et al. The Human Stratum Corneum Prevents Small Gold Nanoparticle Penetration and Their Potential Toxic Metabolic Consequences. J Nanomater. 2012;2012:8.
  13. Chen Xδ, Fernando GJδ, Raphael APδ, et al. Rapid kinetics to peak serum antibodies is achieved following influenza vaccination by dry-coated densely packed microprojections to skin. J Control Release. 2012;158(1):78-84. δEqual contributors.
  14. Lin LL, Prow TW, Raphael AP, et al. Microparticle and microneedle drug delivery in human skin. Wound Repair and Regen. 2012;20(5):A73-A73.
  15. Lin LL, Sundh D, Raphael AP, et al. Removing nanoparticles from human skin. Wound Repair Regen. 2012;20(5):A64-A64.
  16. Labouta HI, Liu DC, Lin LL, Butler MK, Grice JE, Raphael AP, et al. Gold nanoparticle penetration and reduced metabolism in human skin by toluene. Pharm Res. 2011;28(11):2931-44.
  17. Konig K, Raphael AP, et al. Applications of multiphoton tomographs and femtosecond laser nanoprocessing microscopes in drug delivery research. Adv Drug Deliv Rev. 2011;63(4-5):388-404.
  18. Crichton ML, Donose BC, Chen X, Raphael AP, et al. The viscoelastic, hyperelastic and scale dependent behaviour of freshly excised individual skin layers. Biomaterials. 2011;32(20):4670-81.
  19. Chen XF, Corbett HJ, Yukiko SR, Raphael AP, et al. Site-Selectively Coated, Densely-Packed Microprojection Array Patches for Targeted Delivery of Vaccines to Skin. Adv Funct Mater. 2011;21(3):464-73.
  20. Raphael AP, et al. Targeted, needle-free vaccinations in skin using multilayered, densely-packed dissolving microprojection arrays. Small. 2010;6(16):1785-93.
  21. Prow TW, Chen X, Prow NA, Fernando GJ, Tan CS, Raphael AP, et al. Nanopatch-targeted skin vaccination against West Nile Virus and Chikungunya virus in mice. Small. 2010;6(16):1776-84.

PATENTS AND PATENT APPLICATIONS

  1. Raphael AP (35%), Prow TW (35%), Chen X (8%), Kendall MA (22%); Patch Production. Australia. Patent no. WO/2010/071918. 2010.
  2. Raphael AP (50%), Prow TW (50%); Textured Applicator for Applying Microparticles. Australia. Patent no. WO/2014/094067. 2012.

CHAPTERS

  1. Prow TW, Raphael AP and Hang L. (2012) Nanodermatology Imaging. Nancy Montiero-Rivière (ed.). New York, NY, Informa Healthcare USA, Inc. Accepted.
  2. Raphael AP and Prow TW. (2012) Using single and multiphoton to assess new topical drug delivery strategies in volunteers. Percutaneous Penetration Enhancers. Howard I. Maibach (ed.). New York, NY, Taylor & Francis. Accepted.

Research fields

Dermatology, Drug Delivery, Biomedical Engineering