Prof Andrew Perkins

MB BS (Hons), PhD, FRACP, FRCPA

Head of Blood Cancers Program, Diamantina Health Partners, Metro South Health Care and Co-leader of Blood and Bone Diseases Program, Mater-UQ

About me

Professor Perkins is a clinician-scientist with a long standing interest in the transcriptional control of blood development and leukemogenesis. Dr Perkins research focuses on inherited and acquired disorders of blood cell production including myeloproliferative neoplams and myelodysplastic syndromes.

Dr Perkins trained at RPA Hospital in Sydney in clinical and laboratory haematology, undertook his PhD in genetics at Walter and Eliza Hall Institute, then post-doctoral studies at Harvard University before returning to Australia in 1997.

He has clinical appointments in Mater Pathology and Queensland Health at the Princess Alexandra Hospital. He also has an adjunct appointment in the School of Biomedical Sciences at the University of Queensland.

Projects

Personalised Treatment of Blood Cancers based on Genomics, Genomics of Myeloproliferative Neoplasms, Genetics of HSC biology, Kruppel like master control genes in organogenesis, lncRNAs

Publications

Top Ten Publications:

1. Stem cell transcriptome profiling via massive scale shotgun short tag sequencing. Nicole Cloonan, Alistair R.R. Forrest, Gabriel Kolle, Brooke B.A. Gardiner, Geoffrey J. Faulkner, Mellissa K. Brown, Darrin F. Taylor, Anita Steptoe, Graeme Bethel, Alan J. Robertson, Andrew C. Perkins, Stephen Bruce, Clarence Lee, Heather Peckham, Kevin McKernan, Sean M. Grimmond. Nature Methods (2008) 5(7):613-9 IF=19.3 Cit=434 (GS 647)2. Lethal -thalassemia in mice lacking the erythroid CACCC-transcription factor EKLF. Perkins AC, Sharp AH, Orkin SH. Nature 375; 318-322 (1995).  IF=36.3, Cit=426 (GS 515)3. An essential role in liver development for transcription factor XBP-1. Reimold AM, Etkin A, Clauss I, Perkins AC, Friend DS, Zhang J, Horton HF, Scott A, Orkin SH, Byrne MC, Grusby MJ, Glimcher LH. Genes Dev.; 14 (2):152-7 (2000).  IF 12.9 Cit=261 (GS 363)4. Long non-coding RNAs in mouse ES cell pluripotency and differentiation. Marcel E. Dinger, Paulo P. Amaral , Tim R. Mercer, Ken C. Pang, Stephen Bruce, Brooke Gardiner, Marjan Askarian-Amiri,  Giulia M.E.A. Solda, Cas Simons, Susan M. Sunkin Mark L. Crowe, Sean M. Grimmond, Andrew C. Perkins, John S. Mattick. Genome Research (2008) 18(9):1433-45 IF13.6 Cit=222 (GS 304)5. Isolation and characterization of the cDNA encoding BKLF/TEF-2, a major CACCC-box binding protein in erythroid cells and selected other cells. Crossley MP, Whitelaw E, Perkins AC, Williams G, Fujiwara Y, Orkin SH. Mol. Cell. Biol. 16 (4); 1695-1705 (1996). IF 5.5, Cit=171 (GS 205)6. Homeobox gene expression plus autocrine growth factor production elicits myeloid leukemia. Perkins AC, Kongsuwan K, Visvader J, Adams JM, Cory S. PNAS  87; 8398-8402 (1990). IF 9.7, Cit=164 (GS 153)7. SEK1 deficiency reveals mitogen-activated protein kinase cascade cross-regulation and leads to abnormal hepatogenesis. Ganiatsas S, Kwee L, Fujiwara Y, Perkins AC, Ikeda T, Orkin SH, Lebow MA, and Zon LI. PNAS 95 (12):6881-6 (1998).  IF 9.7 Cit=157 (GS 193)8. Thrombopoietin rescues in vitro erythroid colony formation from mouse embryos lacking the erythropoietin receptor. Keiran MW, Perkins AC, Orkin SH and Zon LI. PNAS 93; 9126-9131 (1996) IF=9.7 Cit=118 (GS 156)9. A global role for EKLF in definitive and primitive haematopoiesis. Hodge D, Coghill E, Maguire T, Keys J, Hartmann B, Weiss, M, McDowell, A, Grimmond S, Perkins AC. Blood 107 (8): 3357-3370 (2006) IF 9.9 Cit=110 (GS 153)10. Silencing of human fetal-globin expression is impaired in the absence of the adult -globin gene activator protein, EKLF. Perkins AC, Gaensler KML, Orkin, SH. PNAS 93; 12267-12271 (1996).  IF=9.7 Cit=112 (GS 135)

Top Five Publications in past five years:

11. A global role for KLF1 in erythropoiesis revealed by ChIP-seq in primary erythroid cells. Tallack MR, Whitington T, Yuen WS, Wainwright EN, Keys JR, Gardiner BB, Nourbakhsh E, Cloonan N, Grimmond SM, Bailey TL, Perkins AC. Genome Research  (2010) 20 (8)  p1052-1063. IF=13.6 Cit=67 (GS 90)12. Evolution of gene function and regulatory control after whole-genome duplication: Comparative analyses in vertebrates. Karin Sonja Kassahn, Vinh Toan Dang, Simon J. Wilkins, Andrew C. Perkins, and Mark A. Ragan. Genome Research (2009) 19:1404-1418  IF=13.6 Cit=50 (GS 69)13. Targeted disruption of the Basic Krüppel-like Factor (Klf3) gene reveals a role in adipogenesis. Nancy Sue, Briony Jack, Sally Eaton, Richard Pearson, Alister Funnell, Jeremy Turner, Robert Czolij, Gareth Denyer, Bob Bao, Juan Carlos Molero, David James, Andrew Perkins, Yuko Fujiwara, Stuart Orkin, Kim Bell-Anderson and Merlin Crossley. Mol Cell Biol.  (2008) 28(12):3967-78 IF 5.5 Cit=47 (GS 65)14. Complex architecture and regulated expression of the Sox2ot locus during vertebrate development. Paulo P. Amaral, Christine Neyt, Simon J. Wilkins, Marjan Askarian-Amiri, Susan M. Sunkin, Andrew C. Perkins, John S. Mattick. RNA (2009) Nov 15 (11):2013-27. IF=5.1 Cit=35 (GS 49)15. Novel roles for Klf1 in erythropoiesis revealed by mRNA-seq. Michael R. Tallack, Lei Sun, Graham W. Magor, Stephen Huang, Sally V. Fry, Evgeny A. Glazov, Timothy L. Bailey and Andrew C. Perkins. Genome Research (2012) Dec; 22(12):2385-98. IF=14.4 Cit=15 (GS 21).

Research fields

Genomics, Stem Cell Biology, Transcriptional Regulation, Blood Cancers, Myeloproliferative Neoplasms