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PUBLICATIONS SUPPORTED BY THE TRI PRECLINICAL IMAGING FACILITY

2023

  • Thomas PB, Alinezhad S, Joshi A, Sweeney K, Tse BWC, Tevz G, McPherson S, Nelson CC, Williams ED, Vela I. Introduction of Androgen Receptor Targeting shRNA Inhibits Tumor Growth in Patient-Derived Prostate Cancer Xenografts. Current Oncology. 2023; 30(11):9437-9447. Doi: org/10.3390/curroncol30110683. (Instrument used: IVIS Spectrum)
  • Wang Y, Wang L, Soro N, Buenzli PR, Li Z, Green N, Tetsworth K, Erbulut D. Bone Ingrowth Simulation Within the Hexanoid, a Novel Scaffold Design. 3D Printing and Additive Manufacturing. 2023 doi: 10.1089/3dp.2023.0113 (Instrument used: Skyscan)
  • Dargusch MS, Soro N, Demir AG, Venezuela J, Sun Q, Wang Y, Abdal-hay A, Alali AQ, Ivanovski S, Previtali B, Kent D. Optimising degradation and mechanical performance of additively manufactured biodegradable Fe–Mn scaffolds using design strategies based on triply periodic minimal surfaces. Smart Materials in Medicine, Vol 5(1) 127-139, doi: 10.1016/j.smaim.2023.10.003. (Instrument used: Skyscan)
  • Dao QD, Nguyen TV, Nguyen DM, Nguyen NN, Nguyen CV, Nguyen AV. Application of X-ray computed tomography scanning in describing partition curves of dense medium cyclones. Minerals Engineering. 2023. Vol 201, 108164, doi: org/10.1016/j.mineng.2023.108164. (Instrument used: Skyscan)
  • Haridevan H, Barkauskas D, Sokolowski KA, Evans DAC, Martin DJ, and Annamalai PK. X-ray Tomographic Reconstruction for Understanding Lignin-Induced Changes in the Microstructure and Properties of Polyurethane Insulation Foam. ACS Applied Polymer Materials. 2023. 5(9), 6772-6780. doi: 10.1021/acsapm.3c00380 (Instrument used: Skyscan)
  • Lin CL, Pozzebon M, Sokolowski KA, Meehan PA. Experimental investigation on rolling contact wear in grease lubricated spherical roller bearings using microcomputed tomography (μCT). Wear, 2023, Vol 534–535, 205121. Doi: org/10.1016/j.wear.2023.205121. (Instrument used: Skyscan)
  • Bessot A, Gunter J, Waugh D, Clements JA, Hutmacher DW, McGovern J, Bock N. GelMA and Biomimetic Culture Allow the Engineering of Mineralized, Adipose, and Tumor Tissue Human Microenvironments for the Study of Advanced Prostate Cancer In Vitro and In Vivo. Adv Healthc Mater. 2023 Jan 28:e2201701. doi: 10.1002/adhm.202201701. (Instruments used: Molecubes X-Cube, IVIS Spectrum, Skyscan) 
  • Fithri NA, Wu Y, Cowin G, Akhtar F, Tran HDN, Tse B, Westra van Holthe N, Moonshi SS, Peter K, Wang X, Truong NP, Ta HT. Gold-Iron nanoparticle: A unique multimodal theranostic approach for thrombosis. Applied Materials Today. 2023 Vol 31, Apr 101750. doi: 10.1016/j.apmt.2023.101750 (Instruments used: Vevo LAZR)
  • Vazquez-Prada KX, Moonshi SS, Wu Y, Akther F, Tse BWC, Sokolowski KA, Peter K, Wang X, Xu G, Ta HT. A Spiky Silver-Iron Oxide Nanoparticle for Highly Efficient Targeted Photothermal Therapy and Multimodal Imaging of Thrombosis. Small. 2023 Jan 12:e2205744. doi: 10.1002/smll.202205744. (Instruments used: Vevo 2100 LAZR, IVIS Spectrum)
  • Entezam A, Fielding A, Bradley D, Fontanarosa D (2023) Absorbed dose calculation for a realistic CT-derived mouse phantom irradiated with a standard Cs-137 cell irradiator using a Monte Carlo method. PLOS ONE 18(2): e0280765. doi:10.1371/journal.pone.0280765 (Instruments used: Molecubes X-Cube)  

2022

  • Yuan y, Gauthier E, Ouwerkerk D, Fletcher MT, Laycock B. Unravelling biodegradation and toxin release kinetics of poly(3-hydroxybutyrate-co-3-hydroxyvalerate)-based biocomposites in a simulated rumen environment: A preliminary study. Sustainable Materials and Technologies. 2022 Vol 33 e00498. Doi: 10.1016/j.susmat.2022. e00498. (Instruments used: Skyscan) 
  • Mclean N, Bermingham MJ, Colegrove P, Sales A, Soro N, Ng CH, Dargusch MS. Effect of Hot Isostatic Pressing and heat treatments on porosity of Wire Arc Additive Manufactured Al 2319. . 2022 Vol 310. 117769. doi: 10.1016/j.jmatprotec.2022.117769. (Instruments used: Skyscan) 
  • Khan T, Lyons NJ, Gough M, Kwah KKX, Cuda TJ, Snell CE, Tse BW, Sokolowski KA, Pearce LA, Adams TE, Rose SE, Puttick S, Pajic M, Adams MN, He Y, Hooper JD, Kryza T. CUB Domain-Containing Protein 1 (CDCP1) is a rational target for the development of imaging tracers and antibody-drug conjugates for cancer detection and therapy. Theranostics. 2022 Oct 3;12(16):6915-6930. doi: 10.7150/thno.78171 (Instruments used: Inveon, IVIS Spectrum, Wizard 2480) 
  • Weerakoon AT, Cooper C, Sokolowski KA, Meyers IA, Thomson D, Ford PJ, Sexton C, Symons AL. Effect of dentine site on resin and cement adaptation tested using X-ray and electron microscopy to evaluate bond durability and adhesive interfaces. Eur J Oral Sci. 2022 Aug 12:e12890. doi: 10.1111/eos.12890. (Instrument used: Skyscan) 
  • Vidana Pathiranagei S, Gratchev I, Sokolowski KA. Investigation of the microstructural characteristics of heated sandstone by micro-computed tomography technique. Environ Earth Sci 81, 401 (2022). Doi: 10.1007/s12665-022-10514-6 (Instrument used: Skyscan)
  • Singh A, Qu Z, Sharma A, Singh M, Tse B, Ostrikov K, Popat A, Sonar P, Kumeria T. Ultra-bright green carbon dots with excitation-independent fluorescence for bioimaging. J Nanostruct Chem (2022). Doi: 10.1007/s40097-022-00501-5 (Instrument used: IVIS Spectrum) 
  • Soro N, Brodie EG, Abdal-hay A, Alali AQ, Kent D, Dargusch MS. Additive manufacturing of biomimetic Titanium-Tantalum lattices for biomedical implant applications. Materials & Design. 2022, Vol 218, 11688. doi: 10.1016/j.matdes.2022.110688 (Instrument used: Skyscan)
  • Otte JA, Soro N, Yang N, Zou J, Dargusch MS. TiB reinforced lattice structures produced by laser powder bed fusion with high elastic admissible strain. Materials Science and Engineering: A. 2022, 845, 143249. doi: 10.1016/j.msea.2022.143249. (Instrument used: Skyscan)
  • Stables J, Green EK, Sehgal A, Patkar OL, Keshvari S, Taylor I, Ashcroft ME, Grabert K, Wollscheid-Lengeling E, Szymkowiak S, McColl BW, Adamson A, Humphreys NE, Mueller W, Starobova H, Vetter I, Shabestari SK, Blurton-Jones MM, Summers KM, Irvine KM, Pridans C, Hume DA. A kinase-dead Csf1r mutation associated with adult-onset leukoencephalopathy has a dominant inhibitory impact on CSF1R signalling. Development. 2022 Apr 15;149(8):dev200237. doi: 10.1242/dev.200237. Epub 2022 Mar 25. (Instrument used: Skyscan)
  • Tseng HW, Girard D, Millard SM, Alexander KA, Torossian F, Anginot A, Fleming A, Gueguen J, Goriot ME, Clay D, Jose B, Nowlan B, Pettit AR, Salga M, Genêt F, Le Bousse-Kerdilès MC, Banzet S, Levesque JP. Spinal cord injury reprograms muscle fibro-adipogenic progenitors to form heterotopic bones within muscles. 2022 Bone Research 10(1): 22. DOI: 10.1038/s41413-022-00188-y (Instruments used: Inveon
  • Tseng HW, Kulina I, Girard D, Gueguen J, Vaquette C, Salga M, Fleming W, Jose B, Millard SM, Pettit AR, Schroder K, Thomas G, Wheeler L, Genêt F, Banzet S, Alexander KA, Levesque JP. Interleukin-1 is overexpressed in injured muscles following spinal cord injury and promotes neurogenic heterotopic ossification. 2022 J Bone Miner Res DOI: 10.1002/jbmr.4482 (Instruments used: Inveon)
  • Peerun, M. I., Ong, D. E. L., Desha. A strategic review on enhanced DEM simulation and advanced 3-D particle printing techniques to improve pipe-jacking force prediction, Tunnelling and Underground Space Technology. 123, 104415. doi:10.1016/j.tust.2022.104415 (Instruments used: Skyscan)
  • Alexander KA, Tseng H, Kulina I, Fleming W, Vaquette C, Genêt F, Ruitenberg MJ, and Lévesque JP. Lymphocytes Are Not Required for Neurogenic Heterotopic Ossification Development after Spinal Cord Injury. Neurotrauma Reports. Mar 2022.87-96. doi: 10.1089/neur.2021.0072. (Instruments used: Molecubes X-Cube). 
  • Keshvari S, Genz B, Teakle N, Caruso M, Cestari MF, Patkar OL, Tse BWC, Sokolowski KA, Ebersbach H, Jascur J, MacDonald KPA, Miller G, Ramm GA, Pettit AR, Clouston AD, Powell EE, Hume DA, Irvine KM. Therapeutic potential of macrophage colony-stimulating factor (CSF1) in chronic liver disease. Dis Model Mech. 2022 Feb 16:dmm.049387. doi: 10.1242/dmm.049387 (Instruments used: Vevo 2100).
  • Tang YH, Rockstroh A, Sokolowski KA, Lynam LR, Lehman M, Thompson EW, Gregory PA, Nelson CC, Volpert M, Hollier BG. Neuropilin-1 is over-expressed in claudin-low breast cancer and promotes tumor progression through acquisition of stem cell characteristics and RAS/MAPK pathway activation. Breast Cancer Res. 2022 Jan 25;24(1):8. doi: 10.1186/s13058-022-01501-7. (Instruments used: IVIS Spectrum).

2021

  • Debaud C, Tseng HW, Chedik M, Kulina I, Genet F, Ruitenberg MJ, Levesque JP. Local and systemic factors drive ectopic osteogenesis in regenerating muscles of spinal cord-injured mice in a lesion level-dependent manner. 2021 J Neurotrauma 38(15): 2162-2175. DOI: 10.1089/neu.2021.0058 (Instruments used: Inveon)
  • He Y, Khan T, Kryza T, Jones ML, Goh JB, Lyons NJ, Pearce LA, Lee MD, Gough M, Rogers R, Davies CM, Gilks CB, Hodgkinson T, Lourie R, Barry SC, Perrin LC, Williams CC, Puttick S, Adams TE, Munro TP, Hooper JD, Chetty N. Preclinical Evaluation of a Fluorescent Probe Targeting Receptor CDCP1 for Identification of Ovarian Cancer. Mol Pharm. 2021 Sep 6;18(9):3464-3474. doi: 10.1021/acs.molpharmaceut.1c00401 (Instruments used: IVIS Spectrum).
  • McGovern JA, Bock N, Shafiee A, Martine LC, Wagner F, Baldwin JG, Landgraf M, Lahr CA, Meinert C, Williams ED, Pollock PM, Denham J, Russell PJ, Risbridger GP, Clements JA, Loessner D, Holzapfel BM, Hutmacher DW. A humanized orthotopic tumor microenvironment alters the bone metastatic tropism of prostate cancer cells. Commun Biol. 2021 Aug 30;4(1):1014. doi: 10.1038/s42003-021-02527-x.  (Instruments used: IVIS Spectrum)
  • Cuda TJ, He Y, Kryza T, Khan T, Tse BW, Sokolowski KA, Liu C, Lyons N, Gough M, Snell CE, Wyld DK, Rose S, Riddell AD, Stevenson A RL, Thomas PA, Clark DA, Puttick S, Hooper JD, Preclinical Molecular PET-CT Imaging Targeting CDCP1 in Colorectal Cancer, Contrast Media & Molecular Imaging, vol. 2021, Article ID 3153278, 12 pages, 2021. https://doi.org/10.1155/2021/3153278 (Instruments used: Inveon, Wizard 2480)
  • Batoon L, Millard SM, Raggatt LJ, Wu AC, Kaur S, Sun LWH, Williams K, Sandrock C, Ng PY, Irvine KM, Bartnikowski M, Glatt V, Pavlos NJ, Pettit AR. Osteal macrophages support osteoclast-mediated resorption and contribute to bone pathology in a postmenopausal osteoporosis mouse model. J Bone Miner Res. 2021 Jul 19. doi: 10.1002/jbmr.4413. (Instruments used: Skyscan 1272)
  • Sinha R, Ngo MD, Bartlett S, Bielefeldt-Ohmann H, Keshvari S, Hasnain SZ, Donovan ML, Kling JC, Blumenthal A, Chen C, Short KR and Ronacher K (2021) Pre-Diabetes Increases Tuberculosis Disease Severity, While High Body Fat Without Impaired Glucose Tolerance Is Protective. Front. Cell. Infect. Microbiol. 11:691823. doi: 10.3389/fcimb.2021.691823 (Instruments used: Minispec)
  • Keshvari S, Caruso M, Teakle N, Batoon L, Sehgal A, Patkar OL, Ferrari-Cestari M, Snell CE, Chen C, Stevenson A, Davis FM, Bush SJ, Pridans C, Summers KM, Pettit AR, Irvine KM, Hume DA. CSF1R-dependent macrophages control postnatal somatic growth and organ maturation. PLoS Genet. 2021 Jun 3;17(6):e1009605. doi: 10.1371/journal.pgen.1009605. (Instruments used: Skyscan)
  • Batoon L, Millard SM, Raggatt LJ, Sandrock C, Pickering E, Williams K, Sun LWH, Wu AC, Irvine KM, Pivonka P, Glatt V, Wullschleger ME, Hume DA, Pettit AR (2021). Treatment with a long-acting chimeric CSF1 molecule enhances fracture healing of healthy and osteoporotic bones. Biomaterials. doi.org/10.1016/j.biomaterials.2021.120936. (Instruments used: Skyscan)
  • Philp LK, Rockstroh A, Sadowski MC, Taherian Fard A, Lehman M, Tevz G, Libério MS, Bidgood CL, Gunter JH, McPherson S, Bartonicek N, Wade JD, Otvos L, Nelson CC. Leptin antagonism inhibits prostate cancer xenograft growth and progression. Endocr Relat Cancer. 2021 Apr 29;28(5):353-375. doi: 10.1530/ERC-20-0405 (Instruments used: Vevo 2100)
  • Kryza T, Khan T, Lovell S, Harrington BS, Yin J, Porazinski S, Pajic M, Koistinen H, Rantala JK, Dreyer T, Magdolen V, Reuning U, He Y, Tate EW, Hooper JD. Substrate-biased activity-based probes identify proteases that cleave receptor CDCP1. Nat Chem Biol. 2021 Apr 15. doi: 10.1038/s41589-021-00783-w. (Instruments used: IVIS Spectrum)
  • Nowlan B, Futrega K, Williams ED, Doran MR. Human bone marrow-derived stromal cell behavior when injected directly into the bone marrow of NOD-scid-gamma mice pre-conditioned with sub-lethal irradiation. Stem Cell Res Ther. 2021 Apr 12;12(1):231. doi: 10.1186/s13287-021-02297-7 (Instruments used: IVIS Spectrum)
  • Mills RJ, Humphrey SJ, Fortuna PRJ, Lor M, Foster SR, Quaife-Ryan GA, Johnston RL, Dumenil T, Bishop C, Rudraraju R, Rawle DJ, Le T, Zhao W, Lee L, Mackenzie-Kludas C, Mehdiabadi NR, Halliday C, Gilham D, Fu L, Nicholls SJ, Johansson J, Sweeney M, Wong NCW, Kulikowski E, Sokolowski KA, Tse BWC, Devilée L, Voges HK, Reynolds LT, Krumeich S, Mathieson E, Abu-Bonsrah D, Karavendzas K, Griffen B, Titmarsh D, Elliott DA, McMahon J, Suhrbier A, Subbarao K, Porrello ER, Smyth MJ, Engwerda CR, MacDonald KPA, Bald T, James DE, Hudson JE. BET inhibition blocks inflammation-induced cardiac dysfunction and SARS-CoV-2 infection. Cell. 2021 Mar 16:S0092-8674(21)00354-8. doi: 10.1016/j.cell.2021.03.026. (Instruments used: Vevo 2100)
  • Monterosso ME, Futrega K, Lott WB, Vela I, Williams ED, Doran MR. Using the Microwell-mesh to culture microtissues in vitro and as a carrier to implant microtissues in vivo into mice. Sci Rep. 2021 Mar 4;11(1):5118. doi: 10.1038/s41598-021-84154-4. (Instruments used: Vevo 2100, IVIS Spectrum).
  • Liu TY, Bartnikowski M, Wu AC, Veitch M, Sokolowski KA, Millard SM, Pettit AR, Glatt V, Evans CH, Wells JW. Healing of sub-critical femoral osteotomies in mice is unaffected by tacrolimus and deletion of recombination activating gene 1. Eur Cell Mater. 2021 Mar 17;41:345-354. doi: 10.22203/eCM.v041a22. (Instruments used: Skyscan, Faxitron)
  • Romand X, Liu X, Rahman MA, Bhuyan ZA, Douillard C, Arora Kedia R, Stone N, Roest D, Chew ZH, Cameron AJ, Rehaume LM, Bozon A, Habib M, Armitage CW, Nguyen MVC, Favier B, Beagley K, Maurin M, Gaudin P, Thomas R, Wells TJ, Baillet A. Chlamydia-infected Macrophages mediate Interleukin-23 and Tumor Necrosis Factor-driven Reactive Arthritis in SKG Mice. Arthritis Rheumatol. 2021 Jan 16. doi: 10.1002/art.41653.  (Instruments used: IVIS Spectrum)
  • Futrega K, Robey PG, Klein TJ, Crawford RW, Doran MR. A single day of TGF-β1 exposure activates chondrogenic and hypertrophic differentiation pathways in bone marrow-derived stromal cells. Commun Biol. 2021 Jan 4;4(1):29. doi: 10.1038/s42003-020-01520-0.  (Instruments used: Inveon, Skyscan)

2020

  • Alexander KA, Tseng HW, Salga M, Genêt F, Levesque JP. When the Nervous System Turns Skeletal Muscles into Bones: How to Solve the Conundrum of Neurogenic Heterotopic Ossification. Curr Osteoporos Rep. 2020 Dec;18(6):666-676. doi: 10.1007/s11914-020-00636-w. (Instruments used: Inveon)
  • Mansoori B, Silvestris N, Mohammadi A, Khaze V, Baghbani E, Mokhtarzadeh A, Shanehbandi D, Derakhshani A, Duijf PHG, Baradaran B. miR-34a and miR-200c Have an Additive Tumor-Suppressive Effect on Breast Cancer Cells and Patient Prognosis. Genes. 2021; 12(2):267. Doi: 10.3390/genes12020267. (Instruments used: IVIS Spectrum)
  • Soro N, Saintier N, Attar H, Dargusch. Surface and morphological modification of selectively laser melted titanium lattices using a chemical post treatment. Surface and Coatings Technology. 2020, 393, 125794. doi: 10.1016/j.surfcoat.2020.125794 (Instruments used: Skyscan)
  • Tse BW-C, Kryza T, Yeh MC, Dong Y, Sokolowski KA, Walpole C, Dreyer T, Felber J, Harris J, Magdolen V, Russell PJ, Clements JA., KLK4 induces anti-tumor effects in human xenograft mouse models of orthotopic and metastatic prostate cancer. Cancers. 2020.12(12):3501. doi:10.3390/cancers12123501
  • Tseng HW, Kulina I, Salga M, Fleming W, Vaquette C, Genêt F, Levesque JP, Alexander KA. Neurogenic heterotopic ossifications develop independently of granulocyte-colony stimulating factor and neutrophils. J Bone Miner Res. 2020 Jun 22. doi: 10.1002/jbmr.4118. Epub ahead of print. PMID: 32568412.  (Instruments used: Inveon)
  • Levett I, Liao M, Pratt C, Redding M, Laycock B, Pratt S. Designing for effective controlled release in agricultural products: new insights into the complex nature of the polymer–active agent relationship and implications for use. 2020. Journal of the Science of Food and Agriculture. doi/full/10.1002/jsfa.10531  (Instruments used: Skyscan)
  • Dang HP, Shafiee A, Lahr CA, Dargaville TR, Tran PA. Local Doxorubicin Delivery via 3D‐Printed Porous Scaffolds Reduces Systemic Cytotoxicity and Breast Cancer Recurrence in Mice. Adv. Therap.  2020. doi:10.1002/adtp.202000056  (Instruments used: IVIS Spectrum)
  • Yeh MC, Tse BWC, Fletcher NL, Houston ZH, Lund M, Volpert M, Stewart C, Sokolowski KA, Jeet V, Thurecht KJ, Campbell DH, Walsh BJ, Nelson CC, Russell PJ. Targeted beta therapy of human prostate cancer in vivo with Lu-177 labelled Miltuximab® antibody against glypican-1 (GPC-1). European Journal of Nuclear Medicine and Molecular Imaging Research 2020. 10, 46 doi: 10.1186/s13550-020-00637-x (Instruments used: Inveon, IVIS Spectrum, Vevo LAZR, Wizard).
  • Wang H, Burke LJ, Patel J, Tse BW-C, Bridle KR, Cogger VC, Li X, Liu X, Yang H, Crawford DHG, Roberts MS, Gao W, Liang X. Imaging-based vascular-related biomarkers for early detection of acetaminophen-induced liver injury. Theranostics. 2020. doi:10.7150/thno.44900 (Instruments used: Vevo 2100 LAZR).
  • Khan T, He Y, Kryza T, Harrington BS, Gunter JH, Sullivan MA, Cuda T, Rogers R, Davies CM, Broomfield A, Gough M, Wu AC, McGann T, Weroha SJ, Haluska P, Forbes JM, Armes JE, Barry SC, Coward JI, Jagasia N, Chetty N, Snell CE, Lourie R, Perrin LC, Hooper JD. Disruption of Glycogen Utilization Markedly Improves the Efficacy of Carboplatin against Preclinical Models of Clear Cell Ovarian Carcinoma. Cancers (Basel). 2020;12(4):E869. doi:10.3390/cancers12040869 (Instruments used: IVIS Spectrum).
  • Landgraf M, Lahr CA, Kaur I, Shafiee A, Sanchez-Herrero A, Janowicz PW, Ravichandran A, Howard CB, Cifuentes-Rius A, McGovern JA, Voelcker NH, Hutmacher DW. Targeted camptothecin delivery via silicon nanoparticles reduces breast cancer metastasis. Biomaterials. 2020 May;240:119791. doi: 10.1016/j.biomaterials.2020.119791. (Instruments used: Inveon, IVIS Spectrum, Faxitron).
  • Siegers JY, Novakovic B, Hulme KD, Marshall R, Bloxham CJ, Thomas WG, Reichelt ME, Leijten L, van Run P, Knox K, Sokolowski KA, Tse BWC, Chew KY, Christ AN, Howe G, Bruxner TJC, Karolyi M, Pawelka E, Koch RM, Bellmann-Weiler R, Burkert F, Weiss G, Samanta RJ, Openshaw PJM, Bielefeldt-Ohmann H, van Riel D, Short KR. A high fat diet increases influenza A virus-associated cardiovascular damage. J Infect Dis. 2020 Apr 4:jiaa159. doi: 10.1093/infdis/jiaa159. (Instrument: Vevo).
  • Kryza T, Khan T, Puttick S , Li C , Sokolowski KA, Tse BW-C, Cuda T, Lyons N, Gough M, Yin J, Parkin A, Deryugina EI, Quigley JP, Law RHP, Whisstock JC, Riddell AD, Barbour AP, Wyld DK, Thomas PA, Rose S, Snell CE, Pajic M, He Y, Hooper JD. Effective targeting of intact and proteolysed CDCP1 for imaging and treatment of 1 pancreatic ductal adenocarcinoma. Theranostics. 2020; 10(9):4116-4133; doi:10.7150/thno.43589. (Instruments: Inveon, IVIS Spectrum, Wizard).
  • Harrington BS, He Y, Khan T, Puttick S, Conroy PJ, Kryza T, Cuda T, Sokolowski KA, Tse BW-C, Robbins KK, Arachchige BJ, Stehbens SJ, Pollock PM, Reed S, Weroha SJ, Haluska P, Salomon C, Lourie R, Perrin LC, Law RH, Whistock JC, Hooper JD. Anti-CDCP1 immuno-conjugates for detection and inhibition of ovarian cancer. Theranostics. 2020 10(5):2095-2114 doi:10.7150/thno.30736. (Instruments: Inveon, IVIS Spectrum, Wizard)
  • Lahr CA, Landgraf M, Sanchez-Herrero A, Dang HP, Wagner F, Bas O, Bray LJ, Tran P, Holzapfel BM, Shafiee A, McGovern JA, Hutmacher DW. A 3D-printed biomaterials-based platform to advance established therapy avenues against primary bone cancers. Acta Biomater. 2020 Dec;118:69-82. doi: 10.1016/j.actbio.2020.10.006. (Instruments used: IVIS Spectrum, Inveon, Skyscan)
  • Sanchez-Herrero A, Calvo IA, Flandes-Iparraguirre M, Landgraf M, Lahr CA, Shafiee A, Granero-Molto F, Saez B, Mazo MM, Paiva B, de Juan Pardo E, Nicol A, Prosper F, Bray LJ, McGovern JA. Engineering a Humanised Niche to Support Human Haematopoiesis in Mice: Novel Opportunities in Modelling Cancer. Cancers (Basel). 2020 Aug 6;12(8):2205. doi: 10.3390/cancers12082205. (Instruments used: Inveon)

2019

  • McKenna E, Klein TJ, Doran MR, Futrega K. Integration of an ultra-strong poly(lactic-co-glycolic acid) (PLGA) knitted mesh into a thermally induced phase separation (TIPS) PLGA porous structure to yield a thin biphasic scaffold suitable for dermal tissue engineering. Biofabrication. 2019 Dec 4;12(1):015015. (Instrument used: Skyscan) 
  • Landgraf M, Lahr CA, Sanchez-Herrero A, Meinert C, Shokoohmand A, Pollock PM, Hutmacher DW, Shafiee A*, McGovern JA*. Humanized bone facilitates prostate cancer metastasis and recapitulates therapeutic effects of zoledronic acid in vivo. Bone Research. 2019(7):31 (Instrument: Inveon, Vevo, Faxitron, IVIS Spectrum)
  • Thomas PB, Seim I, Jeffery PL, Gahete MD, Maugham M, Crisp GJ, Stacey A, Shah ET, Walpole C, Whiteside EJ, Nelson CC, Herington AC, Luque RM, Veedu RN, Chopin LK. The long non-coding RNA GHSROS facilitates breast cancer cell migration and orthotopic xenograft tumour growth. International Journal of Oncology. 2019. DOI: 10.3892/ijo.2019.4891 (Instrument: IVIS Spectrum)
  • Chaudhary Z, Khan GM, Abeer MM, Pujara N, Tse BW-C, McGuckin MA, Popat M, Kumeria T. Efficient photoacoustic imaging using ICG loaded functionalized mesoporous silica nanoparticles. Biomaterials Science. 2019 (In Press) (Instrument: Vevo LAZR).
  • Galea R, Nel HJ, Talekar M, Liu X, Ooi JD, Huynh M, Hadjigol S, Robson KJ, Ting YT, Cole S, Cochlin K, Hitchcock S, Zeng B, Yekollu S, Boks M, Goh N, Roberts H, Rossjohn J, Reid HH, Boyd BJ, Malaviya R, Shealy DJ, Baker DG, Madakamutil L, Kitching AR, O'Sullivan BJ, Thomas R. PD-L1- and calcitriol-dependent liposomal antigen-specific regulation of systemic inflammatory autoimmune disease. JCI Insight. 2019 Sep 19;4(18). pii: 126025 (Instrument: IVIS Spectrum)
  • Alexander KA*, Tseng HW*, Fleming W, Jose B, Salga M, Kulina I, Millard SM, Pettit AR, Genêt F, Levesque JP. Inhibition of JAK1/2 Tyrosine Kinases Reduces Neurogenic Heterotopic Ossification After Spinal Cord Injury. Front Immunol. 2019 Mar 7;10:377. (Instrument: Inveon)
  • Salga M, Tseng HW, Alexander KA, Jose B, Vaquette C, Debaud C, Gatin L, Genêt F, Levesque JP. Blocking neuromuscular junctions with botulinum toxin A injection enhances neurological heterotopic ossification development after spinal cord injury in mice. Ann Phys Rehabil Med. 2019 May;62(3):189-192 (Instrument: Inveon)
  • Diermann SH, Lu M, Edwards G, Dargusch M, Huang H. In vitro degradation of a unique porous PHBV scaffold manufactured using selective laser sintering. J Biomed Mater Res Part A 2019:107A:154–162. (Instrument: Skyscan 1272).
  • Xiao W, Green TIP, Liang X, Delint RC, Perry G, Roberts MS, Le Vay K, Back CT, Ascione R, Wang H, Race PR, Perriman AW. Designer artificial membrane binding proteins to direct stem cells to the myocardium. Chemical Science. 2019. 10, 7610. (Instrument: Vevo 2100).
  • Huang X, Ali T, Nano T, Blick T, Tse BWC, Sokolowski K, Tourell MC, Lloyd T, Thompson EW, Momot KI, Hugo HJ. Quantification of breast tissue density: Correlation between single-sided portable NMR and micro-CT measurements. Magnetic Resonance Imaging. 2019. 62: 111-120. (Instrument: Inveon).
  • hang CR, Kurniawan ND, Yamada L, Fleming W, Kaminen-Ahola N, Ahola A, Galloway G, Chong S. Early gestational ethanol exposure in mice: Effects on brain structure, energy metabolism and adiposity in adult offspring. Alcohol. 2019 Mar;75:1-10 (Instrument: Piximus)
  • Wagner F, Holzapfel BM, Martine LC, McGovern J, Lahr CA, Boxberg M, Prodinger PM, Grässel S, Loessner D, Hutmacher DW. A humanized bone microenvironment uncovers HIF2 alpha as a latent marker for osteosarcoma. Acta Biomater. 2019 Apr 15;89:372-381. doi: 10.1016/j.actbio.2019.02.051. (Instruments used: IVIS Spectrum)

2018

  • Maradana MR, Yekollu SK, Zeng B, Ellis J, Clouston A, Miller G, Talekar M, Bhuyan ZA, Mahadevaiah S, Powell EE, Irvine KM, Thomas R, O'Sullivan BJ. Immunomodulatory liposomes targeting liver macrophages arrest progression of nonalcoholic steatohepatitis. Metabolism. 2018 Jan;78:80-94. doi: 10.1016/j.metabol.2017.09.002. (Instruments used: IVIS Spectrum)
  • Shafiee A*, McGovern JA*, Lahr CA, Meinert C, Moi D, Wagner F, Landgraf M, De-Juan-Pardo E, Mazzieri R, Hutmacher DW. Immune system augmentation via humanization using stem/progenitor cells and bioengineering in a breast cancer model study. Int J Cancer. 2018 Sep 15;143(6):1470-1482 (Instrument: Inveon, IVIS Spectrum, & Faxitron)
  • Zeng B, Middelberg AP, Gemiarto A, MacDonald K, Baxter AG, Talekar M, Moi D, Tullett KM, Caminschi I, Lahoud MH, Mazzieri R, Dolcetti R, Thomas R. Self-adjuvanting nanoemulsion targeting dendritic cell receptor Clec9A enables antigen-specific immunotherapy. J Clin Invest. 2018 May 1;128(5):1971-1984. (Instrument: IVIS Spectrum)
  • McGovern JA, Shafiee A, Wagner F, Lahr CA, Landgraf M, Meinert C, Williams ED, Russell PJ, Clements JA, Loessner D, Holzapfel BM, Risbridger GP, Hutmacher DW. Humanization of the prostate microenvironment reduces homing of PC3 prostate cancer cells to human tissue-engineered bone. Cancers 2018, 10, 438 (Instrument: IVIS Spectrum & Faxitron)
  • Smith TM, Austin C, Green DR, Joannes-Boyau R, Bailey S, Dumitriu D, Fallon S, Grün R, James HF, Moncel MH, Williams IS, Wood R, Arora M. Wintertime stress, nursing, and lead exposure in Neanderthal children. Sci Adv. 2018 Oct 31;4(10):eaau9483 (Instrument: Skyscan 1272)
  • Kerage D, Soon MSF, Doff BL, Kobayashi T, Nissen MD, Lam PY, Leggatt GR, Mattarollo SR. Therapeutic vaccination with 4-1BB co-stimulation eradicates mouse acute myeloid leukemia. Oncoimmunology. 2018 Jul 26;7(10):e1486952. (Instrument: IVIS Spectrum)
  • Wang H, Li X, Tse BWC, Yang H, Thorling CA, Liu Y, Touraud M, Chouane JB, Liu X, Roberts MS, Liang X. Indocyanine green-incorporating nanoparticles for cancer theranostics. Theranostics 2018; 8(5):1227-1242.

2017

  • Torossian F, Guerton B, Anginot A, Alexander KA, Desterke C, Soave S, Tseng HW, Arouche N, Boutin L, Kulina I, Salga M, Jose B, Pettit AR, Clay D, Rochet N, Vlachos E, Genet G, Debaud C, Denormandie P, Genet F, Sims NA, Banzet S, Levesque JP, Lataillade JJ, Le Bousse-Kerdilès MC. Macrophage-derived oncostatin M contributes to human and mouse neurogenic heterotopic ossifications. JCI Insight. 2017 Nov 2;2(21). pii: 96034 (Instrument: Inveon) 
  • Holzapfel NP, Shokoohmand A, Wagner F, Landgraf M, Champ S, Holzapfel BM, Clements JA, Hutmacher DW, Loessner D. Lycopene reduces ovarian tumor growth and intraperitoneal metastatic load. Am J Cancer Res. 2017 Jun 1;7(6):1322-1336. (Instrument: IVIS Spectrum)
  • Martine LC, Holzapfel BM, McGovern JA, Wagner F, Quent VM, Hesami P, Wunner FM, Vaquette C, De-Juan-Pardo EM, Brown TD, Nowlan B, Wu DJ, Hutmacher CO, Moi D,Oussenko T, Piccinini E, Zandstra PW, Mazzieri R, Lévesque JP, Dalton PD,Taubenberger AV, Hutmacher DW. Engineering a humanized bone organ model in mice to study bone metastases. Nat Protoc. 2017 Apr;12(4):639-663. (Instrument: IVIS Spectrum)

2016

  • Wu AC, He Y, Broomfield A, Paatan NJ, Harrington BS, Tseng HW, Beaven EA, Kiernan DM, Swindle P, Clubb AB, Levesque JP, Winkler IG, Ling MT, Srinivasan B, Hooper JD, Pettit AR. CD169(+) macrophages mediate pathological formation of woven bone in skeletal lesions of prostate cancer. J Pathol. 2016 Jun;239(2):218-30. (Instrument: IVIS Spectrum & Inveon)
  • Harrington BS, He Y, Davies CM, Wallace SJ, Adams MN, Beaven EA, Roche DK, Kennedy C, Chetty NP, Crandon AJ, Flatley C, Oliveira NB, Shannon CM, deFazio A, Tinker AV, Gilks CB, Gabrielli B, Brennan DJ, Coward JI, Armes JE, Perrin LC, Hooper JD. Cell line and patient-derived xenograft models reveal elevated CDCP1 as a target in high-grade serous ovarian cancer. Br J Cancer. 2016 Feb 16;114(4):417-26 (Instrument: IVIS Spectrum)
  • Liang X, Wang H, Grice JE, Li L, Liu X, Xu ZP, Roberts MS. Physiologically Based Pharmacokinetic Model for Long-Circulating Inorganic Nanoparticles. Nano Lett. 2016 Feb 10;16(2):939-45. (Instrument: IVIS Spectrum)
  • He Y, Wu AC, Harrington BS, Davies CM, Wallace SJ, Adams MN, Palmer JS, Roche DK, Hollier BG, Westbrook TF, Hamidi H, Konecny GE, Winterhoff B, Chetty NP, Crandon AJ, Oliveira NB, Shannon CM, Tinker AV, Gilks CB, Coward JI, Lumley JW, Perrin LC, Armes JE, Hooper JD. Elevated CDCP1 predicts poor patient outcome and mediates ovarian clear cell carcinoma by promoting tumor spheroid formation, cell migration and chemoresistance. Oncogene. 2016 Jan 28;35(4):468-78. (Instrument: IVIS Spectrum)
  • Tang KD, Holzapfel BM, Liu J, Lee TK, Ma S, Jovanovic L, An J, Russell PJ,Clements JA, Hutmacher DW, Ling MT. Tie-2 regulates the stemness and metastatic properties of prostate cancer cells. Oncotarget. 2016 Jan 19;7(3):2572-84. (Instrument: IVIS Spectrum)

2015

  • Fuchs AV*, Tse BW*, Pearce AK, Yeh MC, Fletcher NL, Huang SS, Heston WD, Whittaker AK, Russell PJ#, Thurecht KJ#. Evaluation of Polymeric Nanomedicines Targeted to PSMA: Effect of Ligand on Targeting Efficiency. Biomacromolecules. 2015 Oct 12;16(10):3235-47. (Instrument: IVIS Spectrum)
  • Futrega K, Palmer JS, Kinney M, Lott WB, Ungrin MD, Zandstra PW, Doran MR. The microwell-mesh: A novel device and protocol for the high throughput manufacturing of cartilage microtissues. Biomaterials. 2015 Sep;62:1-12. (Instrument: Inveon)
  • Holzapfel BM, Hutmacher DW, Nowlan B, Barbier V, Thibaudeau L, Theodoropoulos C, Hooper JD, Loessner D, Clements JA, Russell PJ, Pettit AR, Winkler IG, Levesque JP. Tissue engineered humanized bone supports human hematopoiesis in vivo. Biomaterials. 2015 Aug;61:103-14. (Instrument: IVIS Spectrum)
  • Tse BW, Cowin GJ, Soekmadji C, Jovanovic L, Vasireddy RS, Ling MT, Khatri A, Liu T, Thierry B, Russell PJ. PSMA-targeting iron oxide magnetic nanoparticles enhance MRI of preclinical prostate cancer. Nanomedicine. 2015 Feb;10(3):375-86. (Instrument: IVIS Spectrum)
  • Thibaudeau L, Taubenberger AV, Theodoropoulos C, Holzapfel BM, Ramuz O, Straub M, Hutmacher DW. New mechanistic insights of integrin β1 in breast cancer bone colonization. Oncotarget. 2015 Jan 1;6(1):332-44. (Instrument: IVIS Spectrum)

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