PUBLICATIONS SUPPORTED BY THE TRI PRECLINICAL IMAGING FACILITY

2020

  • Tse BW-C, Kryza T, Yeh MC, Dong Y, Sokolowski KA, Walpole C, Dreyer T, Felber J, Harris J, Magdolen V, Russell PJ, Clements JA., KLK4 induces anti-tumor effects in human xenograft mouse models of orthotopic and metastatic prostate cancerCancers. 2020.12(12):3501. doi:10.3390/cancers12123501

  • Tseng HW, Kulina I, Salga M, Fleming W, Vaquette C, Genêt F, Levesque JP, Alexander KA. Neurogenic heterotopic ossifications develop independently of granulocyte-colony stimulating factor and neutrophils. J Bone Miner Res. 2020 Jun 22. doi: 10.1002/jbmr.4118. Epub ahead of print. PMID: 32568412.  (Instruments used: Inveon)
  • Levett I, Liao M, Pratt C, Redding M, Laycock B, Pratt S. Designing for effective controlled release in agricultural products: new insights into the complex nature of the polymer–active agent relationship and implications for use. 2020. Journal of the Science of Food and Agriculture. doi/full/10.1002/jsfa.10531  (Instruments used: Skyscan)
  • Dang HP, Shafiee A, Lahr CA, Dargaville TR, Tran PA. Local Doxorubicin Delivery via 3D‐Printed Porous Scaffolds Reduces Systemic Cytotoxicity and Breast Cancer Recurrence in Mice. Adv. Therap.  2020. doi:10.1002/adtp.202000056  (Instruments used: IVIS Spectrum)
  • Yeh MC, Tse BWC, Fletcher NL, Houston ZH, Lund M, Volpert M, Stewart C, Sokolowski KA, Jeet V, Thurecht KJ, Campbell DH, Walsh BJ, Nelson CC, Russell PJ. Targeted beta therapy of human prostate cancer in vivo with Lu-177 labelled Miltuximab® antibody against glypican-1 (GPC-1). European Journal of Nuclear Medicine and Molecular Imaging Research 2020. 10, 46 doi: 10.1186/s13550-020-00637-x (Instruments used: Inveon, IVIS Spectrum, Vevo LAZR, Wizard).
  • Wang H, Burke LJ, Patel J, Tse BW-C, Bridle KR, Cogger VC, Li X, Liu X, Yang H, Crawford DHG, Roberts MS, Gao W, Liang X. Imaging-based vascular-related biomarkers for early detection of acetaminophen-induced liver injury. Theranostics. 2020. doi:10.7150/thno.44900 (Instruments used: Vevo 2100 LAZR).
  • Khan T, He Y, Kryza T, Harrington BS, Gunter JH, Sullivan MA, Cuda T, Rogers R, Davies CM, Broomfield A, Gough M, Wu AC, McGann T, Weroha SJ, Haluska P, Forbes JM, Armes JE, Barry SC, Coward JI, Jagasia N, Chetty N, Snell CE, Lourie R, Perrin LC, Hooper JD. Disruption of Glycogen Utilization Markedly Improves the Efficacy of Carboplatin against Preclinical Models of Clear Cell Ovarian Carcinoma. Cancers (Basel). 2020;12(4):E869. doi:10.3390/cancers12040869 (Instruments used: IVIS Spectrum).
  • Landgraf M, Lahr CA, Kaur I, Shafiee A, Sanchez-Herrero A, Janowicz PW, Ravichandran A, Howard CB, Cifuentes-Rius A, McGovern JA, Voelcker NH, Hutmacher DW. Targeted camptothecin delivery via silicon nanoparticles reduces breast cancer metastasis. Biomaterials. 2020 May;240:119791. doi: 10.1016/j.biomaterials.2020.119791. (Instruments used: Inveon, IVIS Spectrum, Faxitron).
  • Siegers JY, Novakovic B, Hulme KD, Marshall R, Bloxham CJ, Thomas WG, Reichelt ME, Leijten L, van Run P, Knox K, Sokolowski KA, Tse BWC, Chew KY, Christ AN, Howe G, Bruxner TJC, Karolyi M, Pawelka E, Koch RM, Bellmann-Weiler R, Burkert F, Weiss G, Samanta RJ, Openshaw PJM, Bielefeldt-Ohmann H, van Riel D, Short KR. A high fat diet increases influenza A virus-associated cardiovascular damage. J Infect Dis. 2020 Apr 4:jiaa159. doi: 10.1093/infdis/jiaa159. (Instrument: Vevo).
  • Kryza T, Khan T, Puttick S , Li C , Sokolowski KA, Tse BW-C, Cuda T, Lyons N, Gough M, Yin J, Parkin A, Deryugina EI, Quigley JP, Law RHP, Whisstock JC, Riddell AD, Barbour AP, Wyld DK, Thomas PA, Rose S, Snell CE, Pajic M, He Y, Hooper JD. Effective targeting of intact and proteolysed CDCP1 for imaging and treatment of 1 pancreatic ductal adenocarcinoma. Theranostics. 2020; 10(9):4116-4133; doi:10.7150/thno.43589. (Instruments: Inveon, IVIS Spectrum, Wizard).
  • Harrington BS, He Y, Khan T, Puttick S, Conroy PJ, Kryza T, Cuda T, Sokolowski KA, Tse BW-C, Robbins KK, Arachchige BJ, Stehbens SJ, Pollock PM, Reed S, Weroha SJ, Haluska P, Salomon C, Lourie R, Perrin LC, Law RH, Whistock JC, Hooper JD. Anti-CDCP1 immuno-conjugates for detection and inhibition of ovarian cancer. Theranostics. 2020 10(5):2095-2114 doi:10.7150/thno.30736. (Instruments: Inveon, IVIS Spectrum, Wizard)

2019

  • Landgraf M, Lahr CA, Sanchez-Herrero A, Meinert C, Shokoohmand A, Pollock PM, Hutmacher DW, Shafiee A*, McGovern JA*. Humanized bone facilitates prostate cancer metastasis and recapitulates therapeutic effects of zoledronic acid in vivo. Bone Research. 2019(7):31 (Instrument: Inveon, Vevo, Faxitron, IVIS Spectrum)
  • Thomas PB, Seim I, Jeffery PL, Gahete MD, Maugham M, Crisp GJ, Stacey A, Shah ET, Walpole C, Whiteside EJ, Nelson CC, Herington AC, Luque RM, Veedu RN, Chopin LK. The long non-coding RNA GHSROS facilitates breast cancer cell migration and orthotopic xenograft tumour growth. International Journal of Oncology. 2019. DOI: 10.3892/ijo.2019.4891 (Instrument: IVIS Spectrum)
  • Chaudhary Z, Khan GM, Abeer MM, Pujara N, Tse BW-C, McGuckin MA, Popat M, Kumeria T. Efficient photoacoustic imaging using ICG loaded functionalized mesoporous silica nanoparticles. Biomaterials Science. 2019 (In Press) (Instrument: Vevo LAZR).
  • Galea R, Nel HJ, Talekar M, Liu X, Ooi JD, Huynh M, Hadjigol S, Robson KJ, Ting YT, Cole S, Cochlin K, Hitchcock S, Zeng B, Yekollu S, Boks M, Goh N, Roberts H, Rossjohn J, Reid HH, Boyd BJ, Malaviya R, Shealy DJ, Baker DG, Madakamutil L, Kitching AR, O'Sullivan BJ, Thomas R. PD-L1- and calcitriol-dependent liposomal antigen-specific regulation of systemic inflammatory autoimmune disease. JCI Insight. 2019 Sep 19;4(18). pii: 126025 (Instrument: IVIS Spectrum)
  • Alexander KA*, Tseng HW*, Fleming W, Jose B, Salga M, Kulina I, Millard SM, Pettit AR, Genêt F, Levesque JP. Inhibition of JAK1/2 Tyrosine Kinases Reduces Neurogenic Heterotopic Ossification After Spinal Cord Injury. Front Immunol. 2019 Mar 7;10:377. (Instrument: Inveon)
  • Salga M, Tseng HW, Alexander KA, Jose B, Vaquette C, Debaud C, Gatin L, Genêt F, Levesque JP. Blocking neuromuscular junctions with botulinum toxin A injection enhances neurological heterotopic ossification development after spinal cord injury in mice. Ann Phys Rehabil Med. 2019 May;62(3):189-192 (Instrument: Inveon)
  • Diermann SH, Lu M, Edwards G, Dargusch M, Huang H. In vitro degradation of a unique porous PHBV scaffold manufactured using selective laser sintering. J Biomed Mater Res Part A 2019:107A:154–162. (Instrument: Skyscan 1272).
  • Xiao W, Green TIP, Liang X, Delint RC, Perry G, Roberts MS, Le Vay K, Back CT, Ascione R, Wang H, Race PR, Perriman AW. Designer artificial membrane binding proteins to direct stem cells to the myocardium. Chemical Science. 2019. 10, 7610. (Instrument: Vevo 2100).
  • Huang X, Ali T, Nano T, Blick T, Tse BWC, Sokolowski K, Tourell MC, Lloyd T, Thompson EW, Momot KI, Hugo HJ. Quantification of breast tissue density: Correlation between single-sided portable NMR and micro-CT measurements. Magnetic Resonance Imaging. 2019. 62: 111-120. (Instrument: Inveon).
    • Zhang CR, Kurniawan ND, Yamada L, Fleming W, Kaminen-Ahola N, Ahola A, Galloway G, Chong S. Early gestational ethanol exposure in mice: Effects on brain structure, energy metabolism and adiposity in adult offspring. Alcohol. 2019 Mar;75:1-10 (Instrument: Piximus)

    2018

    • Maradana MR, Yekollu SK, Zeng B, Ellis J, Clouston A, Miller G, Talekar M, Bhuyan ZA, Mahadevaiah S, Powell EE, Irvine KM, Thomas R, O'Sullivan BJ. Immunomodulatory liposomes targeting liver macrophages arrest progression of nonalcoholic steatohepatitis. Metabolism. 2018 Jan;78:80-94. doi: 10.1016/j.metabol.2017.09.002. (Instruments used: IVIS Spectrum)
    • Shafiee A*, McGovern JA*, Lahr CA, Meinert C, Moi D, Wagner F, Landgraf M, De-Juan-Pardo E, Mazzieri R, Hutmacher DW. Immune system augmentation via humanization using stem/progenitor cells and bioengineering in a breast cancer model study. Int J Cancer. 2018 Sep 15;143(6):1470-1482 (Instrument: Inveon, IVIS Spectrum, & Faxitron)
    • Zeng B, Middelberg AP, Gemiarto A, MacDonald K, Baxter AG, Talekar M, Moi D, Tullett KM, Caminschi I, Lahoud MH, Mazzieri R, Dolcetti R, Thomas R. Self-adjuvanting nanoemulsion targeting dendritic cell receptor Clec9A enables antigen-specific immunotherapy. J Clin Invest. 2018 May 1;128(5):1971-1984. (Instrument: IVIS Spectrum)
    • McGovern JA, Shafiee A, Wagner F, Lahr CA, Landgraf M, Meinert C, Williams ED, Russell PJ, Clements JA, Loessner D, Holzapfel BM, Risbridger GP, Hutmacher DW. Humanization of the prostate microenvironment reduces homing of PC3 prostate cancer cells to human tissue-engineered bone. Cancers 2018, 10, 438 (Instrument: IVIS Spectrum & Faxitron)
    • Smith TM, Austin C, Green DR, Joannes-Boyau R, Bailey S, Dumitriu D, Fallon S, Grün R, James HF, Moncel MH, Williams IS, Wood R, Arora M. Wintertime stress, nursing, and lead exposure in Neanderthal children. Sci Adv. 2018 Oct 31;4(10):eaau9483 (Instrument: Skyscan 1272)
    • Kerage D, Soon MSF, Doff BL, Kobayashi T, Nissen MD, Lam PY, Leggatt GR, Mattarollo SR. Therapeutic vaccination with 4-1BB co-stimulation eradicates mouse acute myeloid leukemia. Oncoimmunology. 2018 Jul 26;7(10):e1486952. (Instrument: IVIS Spectrum)
    • Wang H, Li X, Tse BWC, Yang H, Thorling CA, Liu Y, Touraud M, Chouane JB, Liu X, Roberts MS, Liang X. Indocyanine green-incorporating nanoparticles for cancer theranostics. Theranostics 2018; 8(5):1227-1242.

    2017

    • Torossian F, Guerton B, Anginot A, Alexander KA, Desterke C, Soave S, Tseng HW, Arouche N, Boutin L, Kulina I, Salga M, Jose B, Pettit AR, Clay D, Rochet N, Vlachos E, Genet G, Debaud C, Denormandie P, Genet F, Sims NA, Banzet S, Levesque JP, Lataillade JJ, Le Bousse-Kerdilès MC. Macrophage-derived oncostatin M contributes to human and mouse neurogenic heterotopic ossifications. JCI Insight. 2017 Nov 2;2(21). pii: 96034 (Instrument: Inveon) 
    • Holzapfel NP, Shokoohmand A, Wagner F, Landgraf M, Champ S, Holzapfel BM, Clements JA, Hutmacher DW, Loessner D. Lycopene reduces ovarian tumor growth and intraperitoneal metastatic load. Am J Cancer Res. 2017 Jun 1;7(6):1322-1336. (Instrument: IVIS Spectrum)
    • Martine LC, Holzapfel BM, McGovern JA, Wagner F, Quent VM, Hesami P, Wunner FM, Vaquette C, De-Juan-Pardo EM, Brown TD, Nowlan B, Wu DJ, Hutmacher CO, Moi D,Oussenko T, Piccinini E, Zandstra PW, Mazzieri R, Lévesque JP, Dalton PD,Taubenberger AV, Hutmacher DW. Engineering a humanized bone organ model in mice to study bone metastases. Nat Protoc. 2017 Apr;12(4):639-663. (Instrument: IVIS Spectrum)

    2016

    • Wu AC, He Y, Broomfield A, Paatan NJ, Harrington BS, Tseng HW, Beaven EA, Kiernan DM, Swindle P, Clubb AB, Levesque JP, Winkler IG, Ling MT, Srinivasan B, Hooper JD, Pettit AR. CD169(+) macrophages mediate pathological formation of woven bone in skeletal lesions of prostate cancer. J Pathol. 2016 Jun;239(2):218-30. (Instrument: IVIS Spectrum & Inveon)
    • Harrington BS, He Y, Davies CM, Wallace SJ, Adams MN, Beaven EA, Roche DK, Kennedy C, Chetty NP, Crandon AJ, Flatley C, Oliveira NB, Shannon CM, deFazio A, Tinker AV, Gilks CB, Gabrielli B, Brennan DJ, Coward JI, Armes JE, Perrin LC, Hooper JD. Cell line and patient-derived xenograft models reveal elevated CDCP1 as a target in high-grade serous ovarian cancer. Br J Cancer. 2016 Feb 16;114(4):417-26 (Instrument: IVIS Spectrum)
    • Liang X, Wang H, Grice JE, Li L, Liu X, Xu ZP, Roberts MS. Physiologically Based Pharmacokinetic Model for Long-Circulating Inorganic Nanoparticles. Nano Lett. 2016 Feb 10;16(2):939-45. (Instrument: IVIS Spectrum)
    • He Y, Wu AC, Harrington BS, Davies CM, Wallace SJ, Adams MN, Palmer JS, Roche DK, Hollier BG, Westbrook TF, Hamidi H, Konecny GE, Winterhoff B, Chetty NP, Crandon AJ, Oliveira NB, Shannon CM, Tinker AV, Gilks CB, Coward JI, Lumley JW, Perrin LC, Armes JE, Hooper JD. Elevated CDCP1 predicts poor patient outcome and mediates ovarian clear cell carcinoma by promoting tumor spheroid formation, cell migration and chemoresistance. Oncogene. 2016 Jan 28;35(4):468-78. (Instrument: IVIS Spectrum)
    • Tang KD, Holzapfel BM, Liu J, Lee TK, Ma S, Jovanovic L, An J, Russell PJ,Clements JA, Hutmacher DW, Ling MT. Tie-2 regulates the stemness and metastatic properties of prostate cancer cells. Oncotarget. 2016 Jan 19;7(3):2572-84. (Instrument: IVIS Spectrum)

    2015

    • Fuchs AV*, Tse BW*, Pearce AK, Yeh MC, Fletcher NL, Huang SS, Heston WD, Whittaker AK, Russell PJ#, Thurecht KJ#. Evaluation of Polymeric Nanomedicines Targeted to PSMA: Effect of Ligand on Targeting Efficiency. Biomacromolecules. 2015 Oct 12;16(10):3235-47. (Instrument: IVIS Spectrum)
    • Futrega K, Palmer JS, Kinney M, Lott WB, Ungrin MD, Zandstra PW, Doran MR. The microwell-mesh: A novel device and protocol for the high throughput manufacturing of cartilage microtissues. Biomaterials. 2015 Sep;62:1-12. (Instrument: Inveon)
    • Holzapfel BM, Hutmacher DW, Nowlan B, Barbier V, Thibaudeau L, Theodoropoulos C, Hooper JD, Loessner D, Clements JA, Russell PJ, Pettit AR, Winkler IG, Levesque JP. Tissue engineered humanized bone supports human hematopoiesis in vivo. Biomaterials. 2015 Aug;61:103-14. (Instrument: IVIS Spectrum)
    • Tse BW, Cowin GJ, Soekmadji C, Jovanovic L, Vasireddy RS, Ling MT, Khatri A, Liu T, Thierry B, Russell PJ. PSMA-targeting iron oxide magnetic nanoparticles enhance MRI of preclinical prostate cancer. Nanomedicine. 2015 Feb;10(3):375-86. (Instrument: IVIS Spectrum)
    • Thibaudeau L, Taubenberger AV, Theodoropoulos C, Holzapfel BM, Ramuz O, Straub M, Hutmacher DW. New mechanistic insights of integrin β1 in breast cancer bone colonization. Oncotarget. 2015 Jan 1;6(1):332-44. (Instrument: IVIS Spectrum)

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