tRANSLATIONAL rESEARCH pROJECTS

The featured translational research projects underway at TRI are identified by their progress along our translational research pathway. As a newly established research institute with an innovative approach to medical research, we are developing models based on the success of existing projects. The translational pathway model allows us to see where research projects are at, and identify individual and common roadblocks to further progress. Each milestone, from T1 to T5, involves achieving significant progress towards answering a clinical question and a positive outcome for a patient.

T1 Projects

T2 Projects

T3 Projects

T4 Projects

T5 Projects

TRI BASED RESEARCHERS: SUBMIT YOUR PROJECT

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READ MORE ABOUT THE TRANSLATIONAL PATHWAY

Projects in detail

Click the links below for detailed information about our featured projects.

Modulating skin regenerative responses to improve wound repair and fight carcinogenesis

Skin disorders, such as hard to heal wounds or the most common skin cancers, are a major burden on the Australian health system. Dr Khosrotehrani’s research vision is to apply the paradigms of regenerative medicine to understand wound healing and skin cancer. 

Advancing breast tissue engineering

Current breast reconstruction options are limited and involve replacing breast with implants, or transferring existing tissue. Tissue engineering presents a promising solution to breast reconstruction by regenerating tissue rather than replacing it. 

Gardasil HPV Vaccine

Australian immunologist Ian Frazer and his late Chinese colleague Jian Zhou, who died in 1999, developed a vaccine against cervical cancer. The method is ground-breaking because it focuses on prevention, which can be life-saving, in particular for women without regular access to healthcare.

Spectroscopy for high risk breast cancer

A magnetic resonance spectroscopy (MRS) technique that monitors biochemical changes in tissue could improve the management of women at risk of breast cancer.

3-D Technology tracks changes in skin legions

The VECTRA Whole Body 360, the first of its kind outside of the United States, will revolutionise the way we map, monitor and diagnose skin conditions and skin cancer. 

Improved response to drug therapy for cancer

Drugs that trap and cluster the Epidermal Growth Factor Receptor (EGFR) on the cell surface can dramatically improve the capacity of the immune system to kill tumour cells following cetuximab therapy.

>  Improved response to drug therapy for cancer 

Theranostic development for prostate cancer

Enhanced imaging, through the use of biocompatible polymeric theranostic nanoparticles, will allow more accurate diagnosis, staging and decision making for men presenting with prostate cancer or on active surveillance programs. 

Liposome Vaccine Strategy

A liposome vaccine strategy to induce antigen-specific tolerance in Rheumatoid Arthritis (RA).

Blood test for sub-tropical grass allergy

This allergy blood test project is meeting the need for better diagnosis and treatment for subtropical grass pollen allergy.

Herpes Simplex Vaccine

Nineteen of the 20 people in a Phase 1 clinical trial for a new vaccine had produced T-cells in response against HSV2 which causes genital herpes.  Around one in six Australians carry the virus that causes itchy skin lesions, up to one in four Australians aged 40-49 have the virus.

Biomarkers for lymphoma

Current issues in lymphoma management include: delays in diagnosis; deciding the appropriate therapeutic strategy; longitudinal monitoring of response and for relapsed disease; and appropriate use of resources. Lymphoma biomarkers can address all these issues, and offer the potential for personalized lymphoma medicine.

Evaluating benefits of Metformin in the treatment of metastatic prostate cancer

Researchers are leading a world first study using a common diabetes treatment, Metformin, to help men undergoing Androgen Deprivation Therapy. 

New approach to treating type 2 diabetes

The project found that the IL-22 cytokine protects the insulin-producing beta cells in the pancreas from stress, to restore natural control of blood glucose in type 2 diabetes.

Minimally invasive technologies for skin cancer

There is a clear unmet need for minimally invasive diagnostics and more effective therapeutics in dermatology.  This project has contributed to this by inventing, developing, patenting and publishing two innovative technologies: Microbiopsy and Foroderm.

Therapeutics for kidney and heart disease

This research led by Professor David Johnson and his team from the Princess Alexandra Hospital (PAH) aims to find cost-effective strategies to reduce cardiovascular morbidity and the progression of chronic kidney disease to improve health and reduce healthcare costs.

> TRI based Researchers: Submit Your Project

> Support medical Research

> Read more about the Translational Pathway