Publish Date: 
Thursday, October 21, 2021 - 11:15

Cell fitness used to determine outcomes in COVID patients

A cell 'fitness' biomarker could be used to help predict health outcomes in COVID-19 patients. The biomarker's link to COVID-19 was identified in a study led by The University of Queensland Diamantina Institute’s TRI-based Dr Arutha Kulasinghe.

In the study, researchers looked at a cellular fitness marker, known as hfwe-Lose, to identify sub-optimal cells in patients who had been hospitalised or died from COVID at the start of the pandemic.

Dr Kulasinghe said they conducted post-mortem analysis on COVID-infected lung tissues and found that the cell fitness marker influenced a person’s immune response to infection.

“We found that patients with acute lung injury had higher levels of the biomarker in their lower respiratory tract and areas of cell death,” he said.

“More importantly, we also found that the cell fitness marker outperformed conventional methods, such as age, inflammation and co-existing diseases, in predicting health outcomes, such as hospitalisation and death, in COVID patients.”

Assessing the level of risk in developing severe COVID infection is an important consideration in the management of the current pandemic.

Dr Kulasinghe said the study findings might be useful in the early triage of patients who test positive for COVID as the cell fitness marker could be identified via a simple nasal swab.

“The cell fitness marker would enable medical teams to identify patients more likely to develop severe symptoms, provide closer monitoring and earlier access to hospitalisation and intensive care,” he said.

“We are now looking to validate our findings in larger patient populations to determine the robustness of the marker.

“The cell fitness marker is part of the body’s process for removing unwanted cells."

This study was conducted in partnership with the University of Copenhagen, and the paper is published in EMBO Molecular Medicine (DOI: 10.15252/emmm.202013714).

This article is republished from UQ Medicine under a Creative Commons license. Read the original article.