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Also known as “bench to bedside” research, translational research aims to convert basic science discoveries into outcomes that directly benefit humans. The best outcomes are achieved through collaboration between multidisciplinary groups to fast track the translation of ideas into better medical products.

The Translational Research Institute (TRI) is unique in Australia, and a world-leader in bench to bedside medical research. At TRI, our mission is to improve and expedite the translation of innovative research into clinical practice.

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Leading the way in translational outcomes

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“Researchers, clinicians and industry are attracted to conducting research and undertaking clinical trials at TRI not just because of our world class facilities and expertise, but also the outstanding support structure we have built. Our ecosystem enables seamless connection to clinic, with patients from the Princess Alexandra Hospital and Queensland Children’s Hospital, supporting true bench to bedside collaboration. Such access is vital to fast-track health outcomes.”

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Clinical Immunologist and researcher Professor Ian Fraser arrived in Brisbane and set about establishing The University of Queensland’s Centre for Immunology and Cancer Research, based at the Princess Alexandra Hospital.

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Professor Frazer was one of the first scientists to study the link between HPV infections and cervical cancer. A chance meeting with molecular virologist, the late Dr Jian Zhou while on sabbatical at Cambridge University in 1989 would lead to a lifesaving discovery.

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Dr Zhou and his research assistant wife, Dr Xiao-Yi Sun, joined Professor Frazer’s UQ lab, experimenting with assembling two proteins to create a virus-like particle resembling the HPV shell. When introduced into the human body, the particles simulated an immunological response that formed the basis of the vaccine.

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A complete patent application on the HPV technology was submitted and in 1995 Frazer and Zhou licenced the technology through CSL to US pharmaceutical company Merck & Co, who used it to develop a vaccine, now sold as Gardasil.

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Over 270 million doses of Gardasil have reached over 130 countries.

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Gardasil9 protects against nine strains of Human Pampiloma Virus giving 90% protection against cervical cancer.

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Our new Translational Manufacturing facility due to open in 2026 will enable exciting medical advances to reach maturity while keeping manufacturing on Australian shores.

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With 1200 sqm of TRI space licensed to biomed startup and commercial organisations, these companies are able to utilise sophisticated and specialised core facilities, including good manufacturing practice (GMP) cleanrooms.

Housing their business at TRI gives them access to translational researchers and clinical trial facilities within a tertiary and academic health precinct.

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